| Gene Symbol | Htra1 |
|---|---|
| Entrez Gene | 65164 |
| Alt Symbol | Prss11 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | HtrA serine peptidase 1 |
| Other Description | high-temperature requirement A serine peptidase 1|protease serine 11|protease, serine, 11 (Igf binding)|serine protease 11|serine protease HTRA1 |
| Swissprots | Q9QZK5 |
| Accessions | EDM17131 EDM17132 Q9QZK5 AF179370 AAD52683 BC081767 AAH81767 FQ220294 FQ223529 FQ228889 FQ228942 FQ229223 FQ229948 NM_031721 NP_113909 |
| Function | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By si |
| Subcellular Location | Secreted {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250}. |
Recombinant Rat Serine protease HTRA1(Htra1) - CSB-YP889905RA CSB-EP889905RA CSB-BP889905RA CSB-MP889905RA from Cusabio
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Recombinant Rat HTRA1 Protein - HTRA1-2972R from Creative Biomart
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Serine protease HTRA1 (Htra1), Recombinant Protein - MBS1415503 from MyBioSource
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