Htra1

Gene Symbol Htra1
Entrez Gene 65164
Alt Symbol Prss11
Species Rat
Gene Type protein-coding
Description HtrA serine peptidase 1
Other Description high-temperature requirement A serine peptidase 1|protease serine 11|protease, serine, 11 (Igf binding)|serine protease 11|serine protease HTRA1
Swissprots Q9QZK5
Accessions EDM17131 EDM17132 Q9QZK5 AF179370 AAD52683 BC081767 AAH81767 FQ220294 FQ223529 FQ228889 FQ228942 FQ229223 FQ229948 NM_031721 NP_113909
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By si
Subcellular Location Secreted {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250}.

CompoZr® Knockout ZFN Kit - CKOZFN55275 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND55275 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HTRA1 siRNA (Rat) - CRR2063 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

HTRA1 - MBS8203492 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat HTRA1 (NM_031721.1) - SHH316049 from Creative biogene

Category siRNA
Species Reactivities Rat

shRNA set against Rat Htra1(NM_031721.1) - SHH136343 from Creative biogene

Category siRNA
Species Reactivities Rat

Rat HTRA1 siRNA - orb296912 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

HTRA1 shRNA Plasmid (Rat) - CHR2063 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat

HTRA1 miRNA 3'UTR clone - MiUTR1R-02555 from Creative biogene

Species Reactivities Rat
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