HSPA8

Gene Symbol	HSPA8
Entrez Gene	3312
Alt Symbol	HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Species	Human
Gene Type	protein-coding
Description	heat shock 70kDa protein 8
Other Description	LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
Swissprots	Q9H3R6 P11142
Accessions	CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
Function	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
Subcellular Location	Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11276205}.
Top Pathways	Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HSPA8 gene - orb91824 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-HSPA8-cDNA-Clone - DC04279 from Abgent, a WuXi AppTec company Prices $872.10 Sizes 10 µg Species Human Accession BC019816

HSPA8 cDNA (ANA11275) - ANA11275 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC019816

HSPA8 - MBS1277444 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007276

HSPA8 - MBS1278065 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC019816

HSPA8 - MBS1267847 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016179

Human HSPA8/HSC70 Gene ORF cDNA clone in cloning vector - HG11329-M from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-His tag - HG11329-NH from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11329-ACG from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11329-NF from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11329-NM from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11329-CF from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11329-CM from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11329-NY from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11329-ANG from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-His tag - HG11329-CH from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11329-ACR from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11329-ANR from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid - HG11329-UT from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11329-M-F from Sino Biological Species Human

Human HSPA8/HSC70 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11329-CY from Sino Biological Species Human

Human HSPA8 ORF Clone (BC019816) - CDCS412822 from Creative biogene Species Human Accession P11142

Human HSPA8 ORF Clone (BC016179) - CDCS412823 from Creative biogene Species Human Accession P11142

Human HSPA8 ORF Clone (BC007276) - CDCS412824 from Creative biogene Species Human Accession P11142

Human HSPA8 ORF clone (NM_006597.3) - CDCB160415 from Creative biogene Species Human

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