HSPA8

Gene Symbol HSPA8
Entrez Gene 3312
Alt Symbol HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Species Human
Gene Type protein-coding
Description heat shock 70kDa protein 8
Other Description LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
Swissprots Q9H3R6 P11142
Accessions CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
Function Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
Subcellular Location Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:11276205}.
Top Pathways Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

HSC 70 CRISPR/Cas9 KO Plasmid (h) - sc-418508 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 HDR Plasmid (h) - sc-418508-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 Double Nickase Plasmid (h) - sc-418508-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 Double Nickase Plasmid (h2) - sc-418508-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 CRISPR Activation Plasmid (h) - sc-418508-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 CRISPR Activation Plasmid (h2) - sc-418508-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 Lentiviral Activation Particles (h) - sc-418508-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 Lentiviral Activation Particles (h2) - sc-418508-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSC 70 siRNA (h) - sc-29349 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSC 70 shRNA Plasmid (h) - sc-29349-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSC 70 shRNA (h) Lentiviral Particles - sc-29349-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSC 70 siRNA (h2) - sc-44263 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSC 70 shRNA Plasmid (h2) - sc-44263-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSC 70 shRNA (h2) Lentiviral Particles - sc-44263-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSPA8/HSC71/Hsc70 RNAi - H00003312-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HSPA8/HSC71/Hsc70 RNAi - H00003312-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU115141 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10368 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10368 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01114 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01114

HSPA8 siRNA (Human) - CRH2265 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSPA8 - MBS8222437 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human HSPA8 siRNA - orb262767 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSPA8 shRNA Plasmid (Human) - CHH2265 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HSPA8 miRNA 3'UTR clone - MiUTR3H-03645 from Creative biogene

Species Reactivities Human
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