Gene Symbol | ATRIP |
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Entrez Gene | 84126 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ATR interacting protein |
Other Description | ATM and Rad3-related-interacting protein|ATR-interacting protein |
Swissprots | Q96CL3 Q8WXE1 Q8NHQ2 Q9HA30 Q8WUG7 A8K714 A8K6A3 B5MEB7 Q69YK9 B2RCE7 B4DU92 |
Accessions | EAW64875 EAW64876 EAW64877 EAW64878 EAW64879 EAW64880 EAW64881 EAW64882 Q8WXE1 AF451323 AAL38042 AK022405 BAB14029 AK291568 BAF84257 AK291829 BAF84518 AK300548 BAG62254 AK315075 BAG37544 AL832917 CAH10621 BC014153 AAH14153 BC020563 AAH20563 BC030597 AAH30597 CB960784 DC402185 DQ892238 ABM83164 DQ895438 ABM86364 NM_001271022 NP_001257951 NM_001271023 NP_001257952 NM_032166 NP_115542 NM_130384 NP_569055 |
Function | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:18283122}. Note=Redistributes to discrete nuclear foci upon DNA damage. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11721054}. |
Top Pathways | Fanconi anemia pathway |
ATRIP CRISPR/Cas9 KO Plasmid (h) - sc-407845 from Santa Cruz Biotechnology
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ATRIP HDR Plasmid (h) - sc-407845-HDR from Santa Cruz Biotechnology
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ATRIP Double Nickase Plasmid (h) - sc-407845-NIC from Santa Cruz Biotechnology
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ATRIP Double Nickase Plasmid (h2) - sc-407845-NIC-2 from Santa Cruz Biotechnology
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ATRIP CRISPR Activation Plasmid (h) - sc-407845-ACT from Santa Cruz Biotechnology
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ATRIP CRISPR Activation Plasmid (h2) - sc-407845-ACT-2 from Santa Cruz Biotechnology
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ATRIP Lentiviral Activation Particles (h) - sc-407845-LAC from Santa Cruz Biotechnology
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ATRIP Lentiviral Activation Particles (h2) - sc-407845-LAC-2 from Santa Cruz Biotechnology
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ATRIP siRNA (h) - sc-44800 from Santa Cruz Biotechnology
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ATRIP shRNA Plasmid (h) - sc-44800-SH from Santa Cruz Biotechnology
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ATRIP shRNA (h) Lentiviral Particles - sc-44800-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3753 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3753 from Sigma-Aldrich
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ATRIP siRNA (Human) - CRJ3309 from Cohesion Biosciences
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ATRIP - MBS8234884 from MyBioSource
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ATRIP - MBS826824 from MyBioSource
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shRNA set against Human ATRIP (NM_032166.3) - SHH243474 from Creative biogene
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ATRIP siRNA - orb219203 from Biorbyt
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Human ATRIP siRNA - orb273810 from Biorbyt
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ATRIP shRNA Plasmid (Human) - CHJ3309 from Cohesion Biosciences
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ATRIP miRNA 3'UTR clone - MiUTR1H-00736 from Creative biogene
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ATRIP miRNA 3'UTR clone - MiUTR1H-00737 from Creative biogene
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ATRIP miRNA 3'UTR clone - MiUTR3H-08604 from Creative biogene
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ATRIP miRNA 3'UTR clone - MiUTR3H-08605 from Creative biogene
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