RBPJ

Gene Symbol	RBPJ
Entrez Gene	3516
Alt Symbol	AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl
Species	Human
Gene Type	protein-coding
Description	recombination signal binding protein for immunoglobulin kappa J region
Other Description	CBF-1|H-2K binding factor-2|RBP-J kappa|RBP-JK|immunoglobulin kappa J region recombination signal binding protein 1|recombining binding protein suppressor of hairless|renal carcinoma antigen NY-REN-30|suppressor of hairless homolog
Swissprots	Q6P1N3 B4DY22 Q06330 Q5XKH9
Accessions	AAA91836 CCQ43315 EAW92846 EAW92847 EAW92848 EAW92849 Q06330 AF086058 AK056944 AK126357 AK302230 BAG63584 AK303244 BAH13924 AK311419 AL600045 BC020780 AAH20780 BC053531 BC053568 BC064976 AAH64976 BE269143 BM472788 BM555733 BM560796 BM680668 BQ216033 CD653684 D14041 BAA21773 DC361185 DC389691 EU446485 ABZ92014 EU832795 ACE87806 GQ129335 ACT64469 L07872 AAA60258 L07874 AAA16253 L07875 AAA16254 L07876 AAA16356 Z36843 XM_005248161 XP_005248218 XM_006713963 XP_006714026 XM_011513840 XP_011512142 XM_011513841 XP_011512143 NM_005349 NP_005340 NM_015874 NP_056958 NM_203283 NP_976028 NM_203284 NP_976029
Function	Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. {ECO:0000269|PubMed:21991380}.
Subcellular Location	Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Top Pathways	Notch signaling pathway, Viral carcinogenesis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RBPJ overexpression lysate - LY401647 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

RBPJ overexpression lysate - LY404367 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RBPJ overexpression lysate - LY404368 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RBPJ overexpression lysate - LY430905 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RBPJ 293 Cell Lysate - 403343 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RBPJ 293 Cell Lysate - 401482 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

csl/RBPJK Overexpression Lysate (Native) - NBL1-15231 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

csl/RBPJK Overexpression Lysate (Native) - NBL1-15233 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

csl/RBPJK Overexpression Lysate (Native) - NBP2-04570 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RBP-Jκ (h): 293T Lysate - sc-116436 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RBP-Jκ (h2): 293T Lysate - sc-117065 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RBP-Jκ (h3): 293T Lysate - sc-177851 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RBPJ Over-expression Lysate Product - GWB-CA6BFD from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

RBPJ Over-expression Lysate Product - GWB-31C068 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

csl/RBPJK Overexpression Lysate (Denatured) - H00003516-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human RBPJ Knockdown Stable Cell Line - CSC-DC013099 from Creative biogene Category Cell Line Species Human

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