RBPJ

Gene Symbol RBPJ
Entrez Gene 3516
Alt Symbol AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl
Species Human
Gene Type protein-coding
Description recombination signal binding protein for immunoglobulin kappa J region
Other Description CBF-1|H-2K binding factor-2|RBP-J kappa|RBP-JK|immunoglobulin kappa J region recombination signal binding protein 1|recombining binding protein suppressor of hairless|renal carcinoma antigen NY-REN-30|suppressor of hairless homolog
Swissprots Q6P1N3 B4DY22 Q06330 Q5XKH9
Accessions AAA91836 CCQ43315 EAW92846 EAW92847 EAW92848 EAW92849 Q06330 AF086058 AK056944 AK126357 AK302230 BAG63584 AK303244 BAH13924 AK311419 AL600045 BC020780 AAH20780 BC053531 BC053568 BC064976 AAH64976 BE269143 BM472788 BM555733 BM560796 BM680668 BQ216033 CD653684 D14041 BAA21773 DC361185 DC389691 EU446485 ABZ92014 EU832795 ACE87806 GQ129335 ACT64469 L07872 AAA60258 L07874 AAA16253 L07875 AAA16254 L07876 AAA16356 Z36843 XM_005248161 XP_005248218 XM_006713963 XP_006714026 XM_011513840 XP_011512142 XM_011513841 XP_011512143 NM_005349 NP_005340 NM_015874 NP_056958 NM_203283 NP_976028 NM_203284 NP_976029
Function Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. {ECO:0000269|PubMed:21991380}.
Subcellular Location Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Top Pathways Notch signaling pathway, Viral carcinogenesis, Epstein-Barr virus infection

RBPSUH (D10A4) XP ® Rabbit mAb - 5313 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A4
Western blot analysis of extracts from various cell lines using RBPSUH (D10A4) XP ® Rabbit mAb.

RBPSUH Antibody - 5442 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cells using RBPSUH Antibody.

RBP-Jκ (H-50) - sc-28713 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RBP-Jκ (H-50): sc-28713. Western blot analysis of RBP-Jκ expression in non-transfected: sc-117752 (A) and human RBP-Jκ transfected: sc-177851 (B) 293T whole cell lysates.

RBP-Jκ (E-15) - sc-55020 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RBP-Jκ (D-20) - sc-8213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RBP-Jκ (N-16) - sc-55021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RBP-Jκ (N-16): sc-55021. Western blot analysis of RBP-Jκ expression in non-transfected: sc-117752 (A) and mouse RBP-Jκ transfected: sc-123024 (B) 293T whole cell lysates.

Anti-RBPJK antibody - ab33065 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RBPJK antibody (ab33065) at 1 µg/ml (Pancreas (Human) Tissue Lysate )SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-RBPJK antibody - ab55366 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-RBPJK antibody - ab37420 from Abcam

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RBPJK antibody [EPR13479] - ab180588 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13479
Immunofluorescent analysis of 4% paraformaldehyde fixed 293 cells labeling RBPJK with ab180588 at 1/100 (green). Dapi shown in blue.

Anti-RBPJK antibody [RPBS3D18] - ab51371 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone RPBS3D18
Lane 1 : Molecular weight markersLane 2 : Anti-RBPJK antibody [RPBS3D18] (ab51371)Lane 1 : As aboveLane 2 : immunizing peptide

Anti-RBPJK antibody - ChIP Grade - ab25949 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RBPJK was immunoprecipitated using 0.5mg PANC1 whole cell extract, 5µg of Rabbit polyclonal to RBPJK and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, PANC1 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab25949.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 56kDa, non specific bands -50kDa: This extra band is heavy chain contamination; RBPJK

Anti-RBPJ Antibody (clone 4E12) - LS-C197505 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4E12
Western Blot analysis of RBPJ expression in transfected 293T cell line by RBPJ monoclonal antibody (M01), clone 4E12.Lane 1: RBPJ transfected lysate(54.3 KDa).Lane 2: Non-transfected lysate.

Anti-RBPJ Antibody - LS-C334209 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of mouse lung, using RBPJ antibody.

Anti-RBPJ Antibody (clone RPBS3D18) - LS-C342348 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone RPBS3D18
Western blot analysis of immunized recombinant protein, using anti-RBPSUH monoclonal antibody.

Anti-RBPJ Antibody (aa258-500) - LS-C186261 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed HeLa using RBP-Jkappa antibody at 1:100 dilution.

Anti-RBPJ Antibody (aa1-29) - LS-C158830 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RBPJ Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-RBPJ Antibody (aa208-500) - LS-C36026 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RBPJ Antibody - LS-C125415 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RBPJ Antibody - LS-C75345 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-RBPJ Antibody (clone RPBS?D18) - LS-C184293 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone RPBS?D18

Anti-RBPJ Antibody - LS-C191250 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBPJ Antibody (aa1-30, Biotin) - LS-C267986 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBPJ Antibody (aa1-30, FITC) - LS-C267987 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBPJ Antibody (aa1-30, Azide-free, HRP) - LS-C267988 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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