| Gene Symbol |
EIF3CL
|
| Entrez Gene |
728689
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit C-like
|
| Other Description |
eIF3 p110|eIF3c|eukaryotic translation initiation factor 3 subunit 8|eukaryotic translation initiation factor 3 subunit C|eukaryotic translation initiation factor 3 subunit C-like protein|eukaryotic translation initiation factor 3, subunit 8, 110kDa-like
|
| Swissprots |
B5ME19
|
| Accessions |
B5ME19 XM_005255535 XP_005255592 NM_001099661 NP_001093131
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
RNA transport
|