Gene Symbol | NTN1 |
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Entrez Gene | 9423 |
Alt Symbol | NTN1L |
Species | Human |
Gene Type | protein-coding |
Description | netrin 1 |
Other Description | epididymis tissue protein Li 131P|netrin 1, mouse, homolog of|netrin-1 |
Swissprots | E9KL51 O95631 |
Accessions | EAW90032 O95631 BC092429 GU727649 ADU87650 U75586 AAD09221 XM_006721595 XP_006721658 NM_004822 NP_004813 |
Function | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. {ECO:0000269|PubMed:15343335}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Tissue Specificity | Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409, ECO:0000269|PubMed:9950216}. |
Top Pathways | Axon guidance |
netrin-1 (C-19) - sc-9292 from Santa Cruz Biotechnology
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netrin-1 (H-104) - sc-20786 from Santa Cruz Biotechnology
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netrin-1 (N-18) - sc-9291 from Santa Cruz Biotechnology
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Anti-Netrin 1 antibody - ab39370 from Abcam
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Anti-Netrin 1 antibody - ab78854 from Abcam
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Anti-Netrin 1 antibody - ab106929 from Abcam
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Anti-Netrin 1 antibody - ab134016 from Abcam
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Anti-Netrin 1 antibody - ab131061 from Abcam
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Anti-Netrin 1 antibody - ab26162 from Abcam
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Anti-Netrin 1 antibody [EPR5428] - ab126729 from Abcam
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Anti-NTN1 / Netrin 1 Antibody - LS-C73264 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C73266 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C124233 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C26934 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C149127 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa484-533) - LS-C291710 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa313-565, Biotin) - LS-C300125 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa313-565, FITC) - LS-C303807 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C343702 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody - LS-C26937 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa313-565) - LS-C295563 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa498-509) IHC-plus™ - LS-B5109 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (Internal, clone EPR5428) - LS-C152379 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (aa568-596) - LS-C203972 from LifeSpan Bioscience
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Anti-NTN1 / Netrin 1 Antibody (Gln533) - LS-C177626 from LifeSpan Bioscience
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