| Gene Symbol |
NTN1
|
| Entrez Gene |
9423
|
| Alt Symbol |
NTN1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
netrin 1
|
| Other Description |
epididymis tissue protein Li 131P|netrin 1, mouse, homolog of|netrin-1
|
| Swissprots |
E9KL51 O95631
|
| Accessions |
EAW90032 O95631 BC092429 GU727649 ADU87650 U75586 AAD09221 XM_006721595 XP_006721658 NM_004822 NP_004813
|
| Function |
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. {ECO:0000269|PubMed:15343335}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409, ECO:0000269|PubMed:9950216}.
|
| Top Pathways |
Axon guidance
|