| Gene Symbol | Abca7 |
|---|---|
| Entrez Gene | 27403 |
| Alt Symbol | ABCX, Abc51 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ATP-binding cassette, sub-family A (ABC1), member 7 |
| Other Description | ATP-binding cassette sub-family A member 7 |
| Swissprots | Q9JL36 Q91V24 |
| Accessions | AAK56863 EDL31613 Q91V24 AF213395 AAF31434 AF287141 AAK56862 AK143653 AK178671 AK194023 AK195405 BC024511 AAH24511 BC036566 BC038521 BC145120 AAI45121 BC150708 AAI50709 XM_006513710 XP_006513773 XM_006513711 XP_006513774 XM_006513712 XP_006513775 XM_006513713 XP_006513776 XM_006513714 XP_006513777 XR_380402 XR_380403 NM_013850 NP_038878 |
| Function | Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:15550377, ECO:0000269|PubMed:16908670}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. |
| Tissue Specificity | Widely expressed with higher expression in brain, lung, adrenal gland and spleen (at protein level). Highly expressed in spleen and hematopoietic tissues. {ECO:0000269|PubMed:11435699, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:15550377}. |
| Top Pathways | ABC transporters |
ABCA7 CRISPR/Cas9 KO Plasmid (m) - sc-424270 from Santa Cruz Biotechnology
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ABCA7 HDR Plasmid (m) - sc-424270-HDR from Santa Cruz Biotechnology
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ABCA7 Double Nickase Plasmid (m) - sc-424270-NIC from Santa Cruz Biotechnology
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ABCA7 Double Nickase Plasmid (m2) - sc-424270-NIC-2 from Santa Cruz Biotechnology
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ABCA7 CRISPR Activation Plasmid (m) - sc-424270-ACT from Santa Cruz Biotechnology
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ABCA7 CRISPR Activation Plasmid (m2) - sc-424270-ACT-2 from Santa Cruz Biotechnology
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ABCA7 Lentiviral Activation Particles (m) - sc-424270-LAC from Santa Cruz Biotechnology
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ABCA7 Lentiviral Activation Particles (m2) - sc-424270-LAC-2 from Santa Cruz Biotechnology
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ABCA7 siRNA (m) - sc-45432 from Santa Cruz Biotechnology
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ABCA7 shRNA Plasmid (m) - sc-45432-SH from Santa Cruz Biotechnology
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ABCA7 shRNA (m) Lentiviral Particles - sc-45432-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU044171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26031 from Sigma-Aldrich
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ABCA7 siRNA (Mouse) - CRM4931 from Cohesion Biosciences
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ABCA7 - MBS8236369 from MyBioSource
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shRNA set against Mouse ABCA7 (NM_013850.1) - SHH228902 from Creative biogene
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shRNA set against Mouse Abca7(NM_013850.1) - SHG022801 from Creative biogene
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Mouse ABCA7 siRNA - orb284407 from Biorbyt
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ABCA7 shRNA Plasmid (Mouse) - CHM4931 from Cohesion Biosciences
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ABCA7 miRNA 3'UTR clone - MiUTR1M-01027 from Creative biogene
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