Gene Symbol | NDC1 |
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Entrez Gene | 55706 |
Alt Symbol | NET3, TMEM48 |
Species | Human |
Gene Type | protein-coding |
Description | NDC1 transmembrane nucleoporin |
Other Description | nuclear division cycle 1 homolog|nucleoporin NDC1|transmembrane protein 48 |
Swissprots | Q9H9T6 B4DHA3 Q9NSG3 Q8NB76 B4DQQ5 Q9NVZ7 Q9NSG4 G3XA81 Q9BTX1 |
Accessions | EAX06731 EAX06732 EAX06733 Q9BTX1 AK001269 BAA91592 AK001593 AK022618 BAB14135 AK025450 AK091439 BAC03665 AK295000 BAG58064 AK298909 BAG61017 AK302910 BAG64078 AL354612 CAB89725 AL354613 CAB89726 BC003082 AAH03082 BM554303 BX648031 DC413103 DQ141696 AAZ73087 XM_006710762 XP_006710825 XM_011541766 XP_011540068 NM_001168551 NP_001162023 NM_018087 NP_060557 NR_033142 |
Function | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
Subcellular Location | Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex. |
Top Pathways | RNA transport |
NDC1 CRISPR/Cas9 KO Plasmid (h) - sc-404678 from Santa Cruz Biotechnology
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NDC1 HDR Plasmid (h) - sc-404678-HDR from Santa Cruz Biotechnology
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NDC1 Double Nickase Plasmid (h) - sc-404678-NIC from Santa Cruz Biotechnology
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NDC1 Double Nickase Plasmid (h2) - sc-404678-NIC-2 from Santa Cruz Biotechnology
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NDC1 CRISPR Activation Plasmid (h) - sc-404678-ACT from Santa Cruz Biotechnology
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NDC1 CRISPR Activation Plasmid (h2) - sc-404678-ACT-2 from Santa Cruz Biotechnology
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NDC1 Lentiviral Activation Particles (h) - sc-404678-LAC from Santa Cruz Biotechnology
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NDC1 Lentiviral Activation Particles (h2) - sc-404678-LAC-2 from Santa Cruz Biotechnology
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NDC1 siRNA (h) - sc-78571 from Santa Cruz Biotechnology
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NDC1 shRNA Plasmid (h) - sc-78571-SH from Santa Cruz Biotechnology
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NDC1 shRNA (h) Lentiviral Particles - sc-78571-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21634 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21634 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01626 from Sigma-Aldrich
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NDC1 siRNA (Human) - CRJ0850 from Cohesion Biosciences
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shRNA set against Human Tmem48 (NM_018087.4) - SHH430612 from Creative biogene
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NDC1 shRNA Plasmid (Human) - CHJ0850 from Cohesion Biosciences
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TMEM48 miRNA 3'UTR clone - MiUTR4H-TG09069 from Creative biogene
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