Gene Symbol | CLCN6 |
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Entrez Gene | 1185 |
Alt Symbol | CLC-6 |
Species | Human |
Gene Type | protein-coding |
Description | chloride channel, voltage-sensitive 6 |
Other Description | chloride transport protein 6 |
Swissprots | Q5SNX1 Q99428 Q5SNW3 Q99429 F8W9R3 O60820 B4DGT7 Q5SNX3 P51797 O60819 Q99427 O60821 P78520 Q17R81 P78521 O60818 A8K1T4 Q5SNX2 Q5SNW2 |
Accessions | AAB69287 AAN40862 CAA67835 EAW71710 EAW71711 EAW71712 EAW71713 EAW71714 EAW71715 EAW71716 P51797 AK289999 BAF82688 AK294764 BAG57898 AK307098 BC050457 BC117420 AAI17421 BC117424 AAI17425 BC143844 D28475 BAA05836 DA229615 DA935587 HQ258635 ADR83387 R20538 X83378 CAA58292 X96391 CAA65255 X99473 CAA67836 X99474 CAA67837 X99475 CAA67838 NM_001256959 NP_001243888 NM_001286 NP_001277 NR_046428 NM_021735 NM_021736 NM_021737 |
Function | Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. |
Subcellular Location | Endosome membrane {ECO:0000269|PubMed:17534424}; Multi-pass membrane protein {ECO:0000269|PubMed:17534424}. Note=Detected in detergent- resistant lipid rafts. |
Tissue Specificity | Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. {ECO:0000269|PubMed:10198195, ECO:0000269|PubMed:8543009, ECO:0000269|PubMed:9224655}. |
CLC-6 CRISPR/Cas9 KO Plasmid (h) - sc-405938 from Santa Cruz Biotechnology
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CLC-6 HDR Plasmid (h) - sc-405938-HDR from Santa Cruz Biotechnology
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CLC-6 Double Nickase Plasmid (h) - sc-405938-NIC from Santa Cruz Biotechnology
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CLC-6 Double Nickase Plasmid (h2) - sc-405938-NIC-2 from Santa Cruz Biotechnology
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CLC-6 CRISPR Activation Plasmid (h) - sc-405938-ACT from Santa Cruz Biotechnology
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CLC-6 CRISPR Activation Plasmid (h2) - sc-405938-ACT-2 from Santa Cruz Biotechnology
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CLC-6 Lentiviral Activation Particles (h) - sc-405938-LAC from Santa Cruz Biotechnology
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CLC-6 Lentiviral Activation Particles (h2) - sc-405938-LAC-2 from Santa Cruz Biotechnology
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CLC-6 siRNA (h) - sc-42387 from Santa Cruz Biotechnology
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CLC-6 shRNA Plasmid (h) - sc-42387-SH from Santa Cruz Biotechnology
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CLC-6 shRNA (h) Lentiviral Particles - sc-42387-V from Santa Cruz Biotechnology
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CLCN6 RNAi - H00001185-R04 from Novus Biologicals
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CLCN6 RNAi - H00001185-R02 from Novus Biologicals
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CLCN6 RNAi - H00001185-R03 from Novus Biologicals
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CLCN6 RNAi - H00001185-R01 from Novus Biologicals
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MISSION® esiRNA - EHU094371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1974 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1974 from Sigma-Aldrich
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CLCN6 siRNA (Human) - CRH0847 from Cohesion Biosciences
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CLCN6 - MBS8221764 from MyBioSource
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shRNA set against Human CLCN6 (NM_001286.3) - SHH264589 from Creative biogene
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CLC-6 CRISPR/Cas9 KO Plasmid (h2) - sc-405938-KO-2 from Santa Cruz Biotechnology
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CLC-6 HDR Plasmid (h2) - sc-405938-HDR-2 from Santa Cruz Biotechnology
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Human CLCN6 siRNA - orb261349 from Biorbyt
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CLCN6 shRNA Plasmid (Human) - CHH0847 from Cohesion Biosciences
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