Gene Symbol | SYNC |
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Entrez Gene | 81493 |
Alt Symbol | SYNC1, SYNCOILIN |
Species | Human |
Gene Type | protein-coding |
Description | syncoilin, intermediate filament protein |
Other Description | intermediate filament protein syncoilin|syncoilin|syncoilin intermediate filament 1|syncoilin, intermediate filament 1|syncoilin-1 |
Swissprots | C9IY41 Q9H7C4 B4DNK8 B4DY58 |
Accessions | EAX07511 EAX07512 Q9H7C4 AA376455 AI752560 AK024707 BAB14970 AK297958 BAG60270 AK302275 BAG63620 BC119700 AAI19701 BC119701 AAI19702 DC355889 DC398945 DN991289 NM_001161708 NP_001155180 NM_030786 NP_110413 |
Function | Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {ECO:0000250|UniProtKB:Q9EPM5}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPM5}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity). {ECO:0000250|UniProtKB:Q9EPM5}. |
Syncoilin CRISPR/Cas9 KO Plasmid (h) - sc-406493 from Santa Cruz Biotechnology
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Syncoilin HDR Plasmid (h) - sc-406493-HDR from Santa Cruz Biotechnology
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Syncoilin Double Nickase Plasmid (h) - sc-406493-NIC from Santa Cruz Biotechnology
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Syncoilin Double Nickase Plasmid (h2) - sc-406493-NIC-2 from Santa Cruz Biotechnology
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Syncoilin CRISPR Activation Plasmid (h) - sc-406493-ACT from Santa Cruz Biotechnology
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Syncoilin CRISPR Activation Plasmid (h2) - sc-406493-ACT-2 from Santa Cruz Biotechnology
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Syncoilin Lentiviral Activation Particles (h) - sc-406493-LAC from Santa Cruz Biotechnology
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Syncoilin Lentiviral Activation Particles (h2) - sc-406493-LAC-2 from Santa Cruz Biotechnology
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Syncoilin siRNA (h) - sc-78581 from Santa Cruz Biotechnology
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Syncoilin shRNA Plasmid (h) - sc-78581-SH from Santa Cruz Biotechnology
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Syncoilin shRNA (h) Lentiviral Particles - sc-78581-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU002261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20889 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20889 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09330 from Sigma-Aldrich
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SYNC siRNA (Human) - CRJ2977 from Cohesion Biosciences
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SYNC - MBS8215243 from MyBioSource
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Syncoilin CRISPR/Cas9 KO Plasmid (h2) - sc-406493-KO-2 from Santa Cruz Biotechnology
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Syncoilin HDR Plasmid (h2) - sc-406493-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SYNC (NM_030786.2) - SHH421640 from Creative biogene
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shRNA set against Human SYNC1(NM_030786.2) - SHL050328 from Creative biogene
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Human SYNC siRNA - orb273478 from Biorbyt
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SYNC shRNA Plasmid (Human) - CHJ2977 from Cohesion Biosciences
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SYNC miRNA 3'UTR clone - MiUTR1H-10108 from Creative biogene
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SYNC miRNA 3'UTR clone - MiUTR3H-12080 from Creative biogene
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