| Gene Symbol |
GRB10
|
| Entrez Gene |
2887
|
| Alt Symbol |
GRB-IR, Grb-10, IRBP, MEG1, RSS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor receptor-bound protein 10
|
| Other Description |
GRB10 adapter protein|GRB10 adaptor protein|insulin receptor-binding protein Grb-IR|maternally expressed gene 1
|
| Swissprots |
A7VJ95 Q92907 D3DVM9 Q92948 O00427 O75222 Q92606 O00701 Q13322 A8K0E6 A4D258
|
| Accessions |
AAC83654 AAC83655 AAS00377 AAS07426 CBH19814 EAL23897 EAW60964 EAW60965 EAW60966 EAW60967 EAW60968 Q13322 AB000731 BAF76353 AF000017 AAC19748 AF000018 AAC19749 AF001534 AAB81134 AI360831 AJ271366 CAB96542 AK021643 AK289511 BAF82200 BC024285 AAH24285 BQ006601 BU598359 BX649028 CX757289 D86962 BAA13198 DA634556 DQ891700 ABM82626 DQ896846 ABM87845 U34355 AAA88819 U66065 AAC50671 U69276 AAB08431 XM_005271760 XP_005271817 XM_005271766 XP_005271823 XM_006715704 XP_006715767 XM_011515303 XP_011513605 XM_011515304 XP_011513606 XM_011515305 XP_011513607 XM_011515306 XP_011513608 XM_011515307 XP_011513609 XM_011515308 XP_011513610 XM_011515309 XP_011513611 XM_011515310 XP_011513612 XM_011515311 XP_011513613 XM_011515312 XP_011513614 XM_011515313 XP_011513615 XM_011515314 XP_011513616 XM_011515315 XP_011513617 XM_011515316 XP_011513618 XM_011515317 XP_011513619 XM_011515318 XP_011513620 XM_011515319 XP_011513621 XM_011515320 XP_011513622 XM_011515321 XP_011513623 XM_011515322 XP_011513624 XM_011515323 XP_011513625 XM_011515324 XP_011513626 NM_001001549 NP_001001549 NM_001001550 NP_001001550 NM_001001555 NP_001001555 NM_005311 NP_005302
|
| Function |
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positi
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. {ECO:0000269|PubMed:11527390}.
|