GRB10

Gene Symbol GRB10
Entrez Gene 2887
Alt Symbol GRB-IR, Grb-10, IRBP, MEG1, RSS
Species Human
Gene Type protein-coding
Description growth factor receptor-bound protein 10
Other Description GRB10 adapter protein|GRB10 adaptor protein|insulin receptor-binding protein Grb-IR|maternally expressed gene 1
Swissprots A7VJ95 Q92907 D3DVM9 Q92948 O00427 O75222 Q92606 O00701 Q13322 A8K0E6 A4D258
Accessions AAC83654 AAC83655 AAS00377 AAS07426 CBH19814 EAL23897 EAW60964 EAW60965 EAW60966 EAW60967 EAW60968 Q13322 AB000731 BAF76353 AF000017 AAC19748 AF000018 AAC19749 AF001534 AAB81134 AI360831 AJ271366 CAB96542 AK021643 AK289511 BAF82200 BC024285 AAH24285 BQ006601 BU598359 BX649028 CX757289 D86962 BAA13198 DA634556 DQ891700 ABM82626 DQ896846 ABM87845 U34355 AAA88819 U66065 AAC50671 U69276 AAB08431 XM_005271760 XP_005271817 XM_005271766 XP_005271823 XM_006715704 XP_006715767 XM_011515303 XP_011513605 XM_011515304 XP_011513606 XM_011515305 XP_011513607 XM_011515306 XP_011513608 XM_011515307 XP_011513609 XM_011515308 XP_011513610 XM_011515309 XP_011513611 XM_011515310 XP_011513612 XM_011515311 XP_011513613 XM_011515312 XP_011513614 XM_011515313 XP_011513615 XM_011515314 XP_011513616 XM_011515315 XP_011513617 XM_011515316 XP_011513618 XM_011515317 XP_011513619 XM_011515318 XP_011513620 XM_011515319 XP_011513621 XM_011515320 XP_011513622 XM_011515321 XP_011513623 XM_011515322 XP_011513624 XM_011515323 XP_011513625 XM_011515324 XP_011513626 NM_001001549 NP_001001549 NM_001001550 NP_001001550 NM_001001555 NP_001001555 NM_005311 NP_005302
Function Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positi
Subcellular Location Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. {ECO:0000269|PubMed:11527390}.

Phospho-GRB10 (Ser476) (D4E6) Rabbit mAb - 11817 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4E6
Western blot analysis of extracts from serum starved NIH/3T3 cells, untreated or treated with insulin (100 nM, 5 min), hIGF-1 #8917 (100 ng/ml, 5 min), or λ phosphatase, using Phospho-GRB10 (Ser476) (D4E6) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

GRB10 Antibody - 3702 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HEK293, SK-N-MC, COS and GRB10-transfected COS cells, using GRB10 Antibody.

Phospho-GRB10 (Tyr67) Antibody - 3701 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

GRB10 (C-11) - sc-74509 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GRB10 (C-11): sc-74509. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

GRB10 (G-3) - sc-74508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GRB10 (G-3): sc-74508. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

GRB10 (H-130) - sc-13955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRB10 (H-130): sc-13955. Western blot analysis of GRB10 expression in HeLa whole cell lysate.

GRB10 (K-20) - sc-1026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

IRBP (H-6) - sc-390218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRBP (H-6): sc-390218. Western blot analysis of IRBP expression in Y79 whole cell lysate.

Anti-GRB10 (phospho Y67) antibody - ab61795 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB10 (phospho Y67) antibody (ab61795) at 1/500 dilutionLane 1 : NIH 3T3 cell extracts treated with Insulin (0.01U/ml, 15mins)Lane 2 : NIH 3T3 cell extracts treated with Insulin (0.01U/ml, 15mins) with immunising peptide

Anti-GRB10 antibody - ab125583 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB10 antibody (ab125583) at 1 µg/mlLane 1 : A20 cell lysateLane 2 : NIH 3T3 cell lysateLysates/proteins at 15 µg per lane.

Anti-GRB10 antibody - ab154029 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GRB10 antibody (ab154029) at 1/2000 dilution + HepG2 whole cell lysate at 30 µg

Anti-GRB10 antibody - ab61771 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRB10 antibody (ab61771) at 1/500 dilutionLane 1 : extracts from NIH/3T3 cells, treated with Insulin (0.01U/ml, 15mins) with no peptideLane 2 : extracts from NIH/3T3 cells, treated with Insulin (0.01U/ml, 15mins) with peptide

Anti-GRB10 antibody - ab153994 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GRB10 antibody (ab153994) at 1/1000 dilution + HeLa cell lysate at 30 µg

Anti-GRB10 antibody - ab55153 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55153 GRB 10 antibody at 1ug/ml.

Anti-GRB10 antibody - N-terminal - ab191043 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of paraffin-embedded Human Mammary cancer tissue lableing GRB10 using ab191043 at 1 µg/ml.

Anti-GRB10 antibody - N-terminal - ab180218 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-GRB10 antibody - N-terminal (ab180218) at 1 µg/ml + HeLa lysate in RIPA buffer at 35 µg

Anti-GRB10 Antibody (N-Terminus) - LS-C7296 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody (phospho-Tyr67) - LS-C7297 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody (phospho-Ser503) - LS-C190080 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody (aa1-50) - LS-C286079 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody - LS-C311196 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody (phospho-Tyr67) - LS-C313594 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRB10 Antibody (phospho-Tyr67) - LS-C199020 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using GRB10 (Phospho-Tyr67) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-GRB10 Antibody (clone 1A7) - LS-C197347 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A7
GRB10 monoclonal antibody (M01), clone 1A7. Western Blot analysis of GRB10 expression in IMR-32.

Anti-GRB10 Antibody (aa33-82) - LS-C117946 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using GRB10 (Ab-67) Antibody. The picture on the right is treated with the synthesized peptide.
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