SH2D1A

Gene Symbol	SH2D1A
Entrez Gene	4068
Alt Symbol	DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD, XLPD1
Species	Human
Gene Type	protein-coding
Description	SH2 domain containing 1A
Other Description	Duncan disease SH2-protein|SH2 domain-containing protein 1A|SLAM associated protein/SH2 domain protein 1A|SLAM-associated protein|T cell signal transduction molecule SAP|T-cell signal transduction molecule SAP|signaling lymphocyte activation molecule-associated protein|signaling lymphocytic activation molecule-associated protein
Swissprots	A8MSW0 O60880 O95386 Q9UNR0 O95384 O95385 O95383 Q6FGS6
Accessions	AFX84033 AFX84034 CAV31693 CAZ78681 EAX11847 EAX11848 EAX11849 EAX11850 EAX11851 O60880 AA190204 AB586694 BAJ19023 AF072930 AAC62630 AF073019 AAC62631 AF100539 AAC79712 AF100540 AAC79713 AF100541 AAC79714 AF100542 AAC79715 AF100543 AAC79716 AK311645 AK311911 BAG34852 AL023657 CAA19222 BC020732 AAH20732 BP432686 CR542031 CAG46828 CR542043 CAG46840 DA007747 DQ895164 ABM86090 EU176322 ABW03773 JX512648 AFX84035 NM_001114937 NP_001108409 NM_002351 NP_002342
Function	Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. {ECO:0000269|PubMed:11282995}.
Top Pathways	Natural killer cell mediated cytotoxicity, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Serum Amyloid P Component, SAP, Human, ELISA Kit - E-EL-H1279 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 3.75 Range 6.25-400ng/mL

Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), Human, ELISA Kit - CSB-EL019036HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Serum Amyloid P Component, SAP, Rabbit, ELISA Kit - E-EL-RB0788 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Serum Amyloid P Component, SAP, Chicken, ELISA Kit - E-EL-Ch0862 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Serum Amyloid P Component, SAP, Porcine, ELISA Kit - E-EL-P0984 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Serum Amyloid P Component, SAP, Guinea Pig, ELISA Kit - E-EL-GP0499 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Serum Amyloid P Component, SAP, Monkey, ELISA Kit - E-EL-MK0717 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human SAP ELISA Kit - HS0241 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine SAP ELISA Kit - AS0241 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

SH2 domain protein 1A, ELISA Kit - MBS9334444 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SAP(Serum Amyloid P Component) ELISA Kit - E-EL-H1279 from Elabscience Category ELISA Kit Sensitivity 3.75 ng/mL Range 6.25—400 ng/mL

Human SAP (Serum Amyloid P Component) CLIA Kit - E-CL-H0833 from Elabscience Category CLIA Kit Sensitivity 0.75 ng/mL Range Average Recovery (%)

SAP, ELISA Kit - MBS584535 from MyBioSource Category ELISA Kit Prices $805.00, $1,220.00 Sizes 1x96 wells, 2x96 wells

SAP, ELISA Kit - MBS2511223 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human SAP is 3.75ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 6.25-400ng/mL

SAP , ELISA Kit - MBS564184 from MyBioSource Category ELISA Kit Prices $490.00 Sizes 1x96 wells

Human Serum Amyloid P Component ELISA - E01S0234 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 ng/ml

Monkey Serum Amyloid P Component ELISA - E09S0234 from BlueGene Biotech Category ELISA Kit

Human SAP(Serum Amyloid P Component) ELISA Kit - E-EL-H1279 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 3.75 ng/mLng/mL Range 6.25~400 ng/mL

Human SAP (Serum Amyloid P Component) CLIA Kit - E-CL-H0833 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 3.75ng/mL Range 6.25-400ng/mL

Human SAP ELISA Kit - abx153015 from Abbexa Category ELISA Kit Range 78.13 pg/ml - 5000 pg/ml

Human SAP ELISA Kit - abx576301 from Abbexa Category ELISA Kit Sensitivity 33 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Custom Human SH2D1A ELISA - ELH-SH2D1A-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human SH2D1A ELISA Kit - orb384799 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human SAP ELISA Kit - E034946 from Biobool Category ELISA Kit Sensitivity 1 ng/ml.

Human MTCP1 ELISA Kit - E090328 from Biobool Category ELISA Kit

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