SH2D1A

Gene Symbol	SH2D1A
Entrez Gene	4068
Alt Symbol	DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD, XLPD1
Species	Human
Gene Type	protein-coding
Description	SH2 domain containing 1A
Other Description	Duncan disease SH2-protein|SH2 domain-containing protein 1A|SLAM associated protein/SH2 domain protein 1A|SLAM-associated protein|T cell signal transduction molecule SAP|T-cell signal transduction molecule SAP|signaling lymphocyte activation molecule-associated protein|signaling lymphocytic activation molecule-associated protein
Swissprots	A8MSW0 O60880 O95386 Q9UNR0 O95384 O95385 O95383 Q6FGS6
Accessions	AFX84033 AFX84034 CAV31693 CAZ78681 EAX11847 EAX11848 EAX11849 EAX11850 EAX11851 O60880 AA190204 AB586694 BAJ19023 AF072930 AAC62630 AF073019 AAC62631 AF100539 AAC79712 AF100540 AAC79713 AF100541 AAC79714 AF100542 AAC79715 AF100543 AAC79716 AK311645 AK311911 BAG34852 AL023657 CAA19222 BC020732 AAH20732 BP432686 CR542031 CAG46828 CR542043 CAG46840 DA007747 DQ895164 ABM86090 EU176322 ABW03773 JX512648 AFX84035 NM_001114937 NP_001108409 NM_002351 NP_002342
Function	Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. {ECO:0000269|PubMed:11282995}.
Top Pathways	Natural killer cell mediated cytotoxicity, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH2D1A/SAP full length protein - ab101112 from Abcam Category Protein Source E. coli Species Human

Human SH2D1A/SAP full length protein - ab173077 from Abcam Category Protein Source E. coli Species Human

Human SH2D1A/SAP peptide - ab50447 from Abcam Category Peptide Species Human

SH2D1A/SAP peptide (73-82) - ab45754 from Abcam Category Peptide Species Human

SH2D1A / SAP Antibody Blocking Peptide - LS-E22093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2D1A / SAP Antibody Blocking Peptide - LS-E22092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2D1A / SAP Antibody Blocking Peptide - LS-E25904 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2D1A / SAP Antibody Blocking Peptide - LS-E25988 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2D1A Recombinant Protein - H00004068-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MTCP1 Recombinant Protein - H00004515-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MTCP1 Recombinant Protein - H00004515-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MTCP1 Protein - NBP2-23218 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human SH2D1A Protein - NBP1-50869 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SH2D1A blocking peptide - GTX89516-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

SH2D1A blocking peptide - GTX89320-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Pig

SH2D1A Protein (OPPA02489) - OPPA02489 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human SAP protein - orb49652 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Human SH2D1A R protein - orb163473 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

Human SH2D1A protein - orb169285 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human SAP protein - orb84769 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Amyloid P protein - 30C-CP1104LY from Fitzgerald Category Protein Prices $275.00 Sizes 250 µg Species Human

Amyloid P protein - 30C-CP1104 from Fitzgerald Category Protein Prices $275.00 Sizes 250 µg

SH2D1A Blocking Peptide - 33R-10098 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SH2D1A protein (His tag) - 80R-1544 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

SH2D1A/SAP Peptide - AC21-0734-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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