Gene Symbol | NIPA1 |
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Entrez Gene | 123606 |
Alt Symbol | FSP3, SPG6 |
Species | Human |
Gene Type | protein-coding |
Description | non imprinted in Prader-Willi/Angelman syndrome 1 |
Other Description | magnesium transporter NIPA1|non-imprinted in Prader-Willi/Angelman syndrome 1|non-imprinted in Prader-Willi/Angelman syndrome region protein 1|spastic paraplegia 6 protein |
Swissprots | Q7KZB0 Q5HYA9 B2RA76 Q7RTP0 Q86XW4 |
Accessions | CAH05585 CCO13782 EAW65549 EAW65550 EAW65551 Q7RTP0 AB089319 BAC67707 AK057846 AK314073 BAG36773 BC025678 AAH25678 BC103705 AAI03706 BC156247 AAI56248 BC172484 AAI72484 BK001020 DAA01477 BX648722 CAI45979 DQ891252 ABM82178 DQ894438 ABM85364 NM_001142275 NP_001135747 NM_144599 NP_653200 |
Function | Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Early endosome {ECO:0000250}. Note=Recruited to the cell membrane in response to low extracellular magnesium. {ECO:0000250}. |
Tissue Specificity | Widely expressed with highest levels in neuronal tissues. {ECO:0000269|PubMed:14508710}. |
NIPA1 CRISPR/Cas9 KO Plasmid (h) - sc-406071 from Santa Cruz Biotechnology
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NIPA1 HDR Plasmid (h) - sc-406071-HDR from Santa Cruz Biotechnology
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NIPA1 Double Nickase Plasmid (h) - sc-406071-NIC from Santa Cruz Biotechnology
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NIPA1 Double Nickase Plasmid (h2) - sc-406071-NIC-2 from Santa Cruz Biotechnology
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NIPA1 CRISPR Activation Plasmid (h) - sc-406071-ACT from Santa Cruz Biotechnology
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NIPA1 CRISPR Activation Plasmid (h2) - sc-406071-ACT-2 from Santa Cruz Biotechnology
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NIPA1 Lentiviral Activation Particles (h) - sc-406071-LAC from Santa Cruz Biotechnology
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NIPA1 Lentiviral Activation Particles (h2) - sc-406071-LAC-2 from Santa Cruz Biotechnology
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NIPA1 siRNA (h) - sc-89918 from Santa Cruz Biotechnology
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NIPA1 shRNA Plasmid (h) - sc-89918-SH from Santa Cruz Biotechnology
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NIPA1 shRNA (h) Lentiviral Particles - sc-89918-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15300 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15300 from Sigma-Aldrich
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NIPA1 siRNA (Human) - CRJ4734 from Cohesion Biosciences
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shRNA set against Human NIPA1 (NM_144599.4) - SHH352472 from Creative biogene
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NIPA1 shRNA Plasmid (Human) - CHJ4734 from Cohesion Biosciences
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