Drd4

Gene Symbol Drd4
Entrez Gene 25432
Alt Symbol D4RA
Species Rat
Gene Type protein-coding
Description dopamine receptor D4
Other Description D(4) dopamine receptor|d(2C) dopamine receptor|dopamine D4 receptor|dopamine receptor 4
Swissprots Q62610 P30729
Accessions AAA18588 EDM12018 EDM12019 P30729 M84009 AAA96716 XM_006230521 XP_006230583 XM_006230522 XP_006230584 NM_012944 NP_037076
Function Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Central nervous system: hypothalamus, thalamus, olfactory bulb, and frontal cortex.
Top Pathways Dopaminergic synapse, Neuroactive ligand-receptor interaction

Anti-Dopamine Receptor D4 antibody - ab20424 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat gastric tissue labelling Dopamine Receptor D4 with ab20424 at 1/1000. Dopamine Receptor D4 was not found in the gastric mucosa (e - left) but was observed in the gastric enteric plexus (f - right). Paraffin sections were baked at 60°C for 2 hours, then deparaffinized in xylene for 20 minutes. Slides were rehydrated in descending concentrations of alcohol and transferred from 70% alcohol solution to distilled water for rinsing. Before staining, slides were pretreated with 10 mM citric acid (pH 6.0) at 92–98°C for 10 min and incubated in 10% normal serum and 0.1% Triton X-100 for 30 min. The sections were then incubated with the primary antibody, followed by the appropriate secondary antibody. Sections were washed in PBS and mounted in 90% glycerin PBS.

D4-Dopamine-Receptor-Antibody - AG1288 from Abgent, a WuXi AppTec company

Prices $475.00, $575.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-D4 Dopamine Receptor antibody (#AG1288), (1:200). 3, 4. Anti-D4 Dopamine Receptor antibody, preincubated with the control peptide antigen.

Monoclonal Antibody to Dopamine Receptor D4 (DRD4) - MAA925Ra21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Dopamine Receptor D4 (DRD4) - PAA925Ra01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Dopamine D4 receptor antibody - TA328801 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-D4 Dopamine Receptor antibody, (1:200). 3, 4. Anti-D4 Dopamine Receptor antibody, preincubated with the control peptide antigen.
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