| Gene Symbol | Drd4 |
|---|---|
| Entrez Gene | 25432 |
| Alt Symbol | D4RA |
| Species | Rat |
| Gene Type | protein-coding |
| Description | dopamine receptor D4 |
| Other Description | D(4) dopamine receptor|d(2C) dopamine receptor|dopamine D4 receptor|dopamine receptor 4 |
| Swissprots | Q62610 P30729 |
| Accessions | AAA18588 EDM12018 EDM12019 P30729 M84009 AAA96716 XM_006230521 XP_006230583 XM_006230522 XP_006230584 NM_012944 NP_037076 |
| Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Central nervous system: hypothalamus, thalamus, olfactory bulb, and frontal cortex. |
| Top Pathways | Dopaminergic synapse, Neuroactive ligand-receptor interaction |
CompoZr® Knockout ZFN Kit - CKOZFN53183 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND53183 from Sigma-Aldrich
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DRD4 siRNA (Rat) - CRR0674 from Cohesion Biosciences
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DRD4 - MBS8240111 from MyBioSource
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shRNA set against Rat Drd4 (NM_012944.1) - SHH281053 from Creative biogene
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shRNA set against Rat Drd4(NM_012944.1) - SHH015797 from Creative biogene
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Rat DRD4 siRNA - orb295523 from Biorbyt
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DRD4 shRNA Plasmid (Rat) - CHR0674 from Cohesion Biosciences
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DRD4 miRNA 3'UTR clone - MiUTR1R-01588 from Creative biogene
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