| Gene Symbol | PARP2 |
|---|---|
| Entrez Gene | 10038 |
| Alt Symbol | ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poly (ADP-ribose) polymerase 2 |
| Other Description | ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase diphtheria toxin-like 2|ADPRT-2|NAD(+) ADP-ribosyltransferase 2|hPARP-2|poly (ADP-ribose) polymerase family, member 2|poly (ADP-ribosyl) transferase-like 2|poly [ADP-ribose] polymerase 2|poly[ADP-ribose] synthase 2|poly[ADP-ribose] synthetase 2 |
| Swissprots | Q9UMR4 Q9NUV2 Q9Y6C8 Q8TEU4 Q9UGN5 |
| Accessions | AAL77437 CAC07442 EAW66476 EAW66477 EAW66478 Q9UGN5 AF085734 AAD29857 AJ236876 CAB41505 AJ236912 CAB65088 AK001980 BAA92017 AK290079 BAF82768 AK300971 BAG62594 BC172288 AAI72288 BU541261 DA354586 XM_005267247 XP_005267304 XM_011536311 XP_011534613 XM_011536312 XP_011534614 XR_943347 NM_001042618 NP_001036083 NM_005484 NP_005475 |
| Function | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus. |
| Top Pathways | Base excision repair |
PARP-2 CRISPR/Cas9 KO Plasmid (h) - sc-402224 from Santa Cruz Biotechnology
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PARP-2 HDR Plasmid (h) - sc-402224-HDR from Santa Cruz Biotechnology
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PARP-2 Double Nickase Plasmid (h) - sc-402224-NIC from Santa Cruz Biotechnology
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PARP-2 Double Nickase Plasmid (h2) - sc-402224-NIC-2 from Santa Cruz Biotechnology
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PARP-2 CRISPR Activation Plasmid (h) - sc-402224-ACT from Santa Cruz Biotechnology
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PARP-2 CRISPR Activation Plasmid (h2) - sc-402224-ACT-2 from Santa Cruz Biotechnology
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PARP-2 Lentiviral Activation Particles (h) - sc-402224-LAC from Santa Cruz Biotechnology
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PARP-2 Lentiviral Activation Particles (h2) - sc-402224-LAC-2 from Santa Cruz Biotechnology
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PARP-2 siRNA (h) - sc-106356 from Santa Cruz Biotechnology
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PARP-2 shRNA Plasmid (h) - sc-106356-SH from Santa Cruz Biotechnology
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PARP-2 shRNA (h) Lentiviral Particles - sc-106356-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1284 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1284 from Sigma-Aldrich
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PARP2 siRNA (Human) - CRH6755 from Cohesion Biosciences
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PARP2 RNAi - H00010038-R01 from Novus Biologicals
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shRNA set against Human PARP2 (NM_005484.3) - SHH370884 from Creative biogene
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shRNA set against Human PARP2(NM_001042618.1) - SHR088764 from Creative biogene
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shRNA set against Human PARP2(NM_005484.3) - SHR088800 from Creative biogene
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PARP2 shRNA Plasmid (Human) - CHH6755 from Cohesion Biosciences
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PARP2 miRNA 3'UTR clone - MiUTR1H-07523 from Creative biogene
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PARP2 miRNA 3'UTR clone - MiUTR1H-07524 from Creative biogene
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