TOPORS

Gene Symbol TOPORS
Entrez Gene 10210
Alt Symbol LUN, P53BP3, RP31, TP53BPL
Species Human
Gene Type protein-coding
Description topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase Topors|SUMO1-protein E3 ligase Topors|topoisomerase I-binding RING finger protein|tumor suppressor p53-binding protein 3
Swissprots Q9NS55 Q9NS56 Q6P987 O43273 Q9UNR9
Accessions AAK12843 AKE32079 EAW58546 Q9NS56 AB045732 BAB03714 AB045733 BAB03715 AF098300 AAD23379 AI934577 AU280552 AV712580 BC060884 AAH60884 BJ993131 BQ007035 BU674865 DA238762 U82939 AAC98530 NM_001195622 NP_001182551 NM_005802 NP_005793
Function Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}.
Subcellular Location Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Tissue Specificity Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. {ECO:0000269|PubMed:10415337, ECO:0000269|PubMed:11278651, ECO:0000269|PubMed:15107820}.

TOPORS (H-127) - sc-292009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TOPORS (H-127): sc-292009. Western blot analysis of TOPORS expression in HeLa (A), Jurkat (B), K-562 (C), HEL 92.1.7 (E) and IMR-32 (F) nuclear extracts and NTERA-2 cl.D1 whole cell lysate (D).

TOPORS (Y-30) - sc-101182 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TOPORS (Y-30): sc-101182. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung, adenosqumous cell carcinoma tissue showing nuclear localization.

Anti-p53 BP3 antibody - ab86383 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testicular seminoma tissue labelling p53 BPS with ab86383 at 1/200 (1µg/ml). Detection: DAB.

Anti-p53 BP3 antibody - ab113274 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab113274 at 1/250 dilution staining p53 BP3 in Formalin-fixed, Paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-p53 BP3 antibody - ab56640 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56640 p53 BP3 antibody at 1ug/ml.

Anti-TOPORS Antibody (clone 5G11) IHC-plus™ - LS-B4493 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5G11
Anti-TOPORS antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4493 concentration 5 ug/ml.

Anti-TOPORS Antibody (aa98-206, Azide-free) - LS-C328838 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TOPORS Antibody (aa995-1045) - LS-C288932 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TOPORS by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-TOPORS used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-TOPORS Antibody (aa995-1045) - LS-C286834 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TOPORS by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-TOPORS used at a dilution of 1:100. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.

TOPORS Antibody (5G11) - H00010210-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5G11
Western Blot: TOPORS Antibody (5G11) [H00010210-M01] - TOPORS expression in HeLa NE ( Cat # L013V3 ).

TOPORS Antibody (4G4) - H00010210-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G4

TOPORS Antibody - NBP1-22976 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TOPORS Antibody [NBP1-22976] - Whole cell lysate from HeLa cells. Affinity purified rabbit anti-TOPORS antibody NBP1-22976. TOPORS was also immunoprecipitated by another rabbit anti-TOPORS antibody.

TOPORS Antibody - NBP1-71941 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: TOPORS Antibody [NBP1-71941] - FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-TOPORS used at a dilution of 1:250

TOPORS Antibody - NBP2-39060 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: TOPORS Antibody [NBP2-39060] - Staining of human testis shows strong nuclear and granular cytoplasmic positivity in cells in seminiferous ducts and Leydig cells.

TOPORS Antibody (6C8) - H00010210-M16 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C8
ELISA: TOPORS Antibody (6C8) [H00010210-M16] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (6B7) - H00010210-M18 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6B7
ELISA: TOPORS Antibody (6B7) [H00010210-M18] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (6D2) - H00010210-M15 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6D2
ELISA: TOPORS Antibody (6D2) [H00010210-M15] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (6F11) - H00010210-M17 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6F11
ELISA: TOPORS Antibody (6F11) [H00010210-M17] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (5G9) - H00010210-M14 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5G9
ELISA: TOPORS Antibody (5G9) [H00010210-M14] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (1A5) - H00010210-M13 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A5
ELISA: TOPORS Antibody (1A5) [H00010210-M13] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody (6E7) - H00010210-M12 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6E7
ELISA: TOPORS Antibody (6E7) [H00010210-M12] - Detection limit for recombinant GST tagged TOPORS is approximately 3ng/ml as a capture antibody.

TOPORS Antibody - H00010210-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

TOPORS Antibody (6D2) - H00010210-M15A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 6D2

TOPORS Antibody (5G9) - H00010210-M14A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 5G9

Monoclonal Anti-TOPORS antibody produced in mouse - SAB1408735 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6D2
<B>Immunoblotting</B><BR/>Monoclonal Anti-TOPORS: <B>Cat. No. SAB1408735</B>: Antibody concentration: 1 μg/mL. Specific band of ~38 kDa using immunogen protein lysate.
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