| Gene Symbol |
ARPP19
|
| Entrez Gene |
10776
|
| Alt Symbol |
ARPP-16, ARPP-19, ARPP16, ENSAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cAMP-regulated phosphoprotein, 19kDa
|
| Other Description |
cAMP-regulated phosphoprotein 19|cyclic AMP phosphoprotein, 19 kD
|
| Swissprots |
Q86TA6 Q9UD70 Q6IAM2 B2R497 P56211
|
| Accessions |
EAW77454 EAW77455 P56211 AF084555 AAD52044 AJ223091 CAA11115 AK023195 AK123616 AK311751 BAG34694 AL833077 CAD89929 AW407610 BC003418 AAH03418 BC100015 AAI00016 BQ422616 CR457132 CAG33413 CV802473 DA647638 HY011638 HY120369 XM_005254132 XP_005254189 XM_005254133 XP_005254190 XM_005254134 XP_005254191 XM_005254135 XP_005254192 NM_001306191 NP_001293120 NM_001306195 NP_001293124 NM_001306196 NP_001293125 NM_006628 NP_006619
|
| Function |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
![Western Blot: ARPP19 Overexpression Lysate (Adult Normal) [NBL1-07731] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ARPP19.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3662_ARPP19%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07731-img0002.jpg)