Gene Symbol | ARPP19 |
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Entrez Gene | 10776 |
Alt Symbol | ARPP-16, ARPP-19, ARPP16, ENSAL |
Species | Human |
Gene Type | protein-coding |
Description | cAMP-regulated phosphoprotein, 19kDa |
Other Description | cAMP-regulated phosphoprotein 19|cyclic AMP phosphoprotein, 19 kD |
Swissprots | Q86TA6 Q9UD70 Q6IAM2 B2R497 P56211 |
Accessions | EAW77454 EAW77455 P56211 AF084555 AAD52044 AJ223091 CAA11115 AK023195 AK123616 AK311751 BAG34694 AL833077 CAD89929 AW407610 BC003418 AAH03418 BC100015 AAI00016 BQ422616 CR457132 CAG33413 CV802473 DA647638 HY011638 HY120369 XM_005254132 XP_005254189 XM_005254133 XP_005254190 XM_005254134 XP_005254191 XM_005254135 XP_005254192 NM_001306191 NP_001293120 NM_001306195 NP_001293124 NM_001306196 NP_001293125 NM_006628 NP_006619 |
Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
ARPP-19 CRISPR/Cas9 KO Plasmid (h) - sc-416375 from Santa Cruz Biotechnology
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ARPP-19 HDR Plasmid (h) - sc-416375-HDR from Santa Cruz Biotechnology
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ARPP-19 Double Nickase Plasmid (h) - sc-416375-NIC from Santa Cruz Biotechnology
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ARPP-19 Double Nickase Plasmid (h2) - sc-416375-NIC-2 from Santa Cruz Biotechnology
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ARPP-19 CRISPR Activation Plasmid (h) - sc-416375-ACT from Santa Cruz Biotechnology
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ARPP-19 CRISPR Activation Plasmid (h2) - sc-416375-ACT-2 from Santa Cruz Biotechnology
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ARPP-19 Lentiviral Activation Particles (h) - sc-416375-LAC from Santa Cruz Biotechnology
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ARPP-19 Lentiviral Activation Particles (h2) - sc-416375-LAC-2 from Santa Cruz Biotechnology
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ARPP-19 siRNA (h) - sc-89926 from Santa Cruz Biotechnology
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ARPP-19 shRNA Plasmid (h) - sc-89926-SH from Santa Cruz Biotechnology
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ARPP-19 shRNA (h) Lentiviral Particles - sc-89926-V from Santa Cruz Biotechnology
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ARPP19 RNAi - H00010776-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3534 from Sigma-Aldrich
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ARPP19 siRNA (Human) - CRH7343 from Cohesion Biosciences
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ARPP19 - MBS8218908 from MyBioSource
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shRNA set against Human Arpp19 (NM_006628.4) - SHH240702 from Creative biogene
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shRNA set against Human ARPP-19(NM_006628.4) - SHG074053 from Creative biogene
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Human ARPP19 siRNA - orb267845 from Biorbyt
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ARPP19 shRNA Plasmid (Human) - CHH7343 from Cohesion Biosciences
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ARPP19 miRNA 3'UTR clone - MiUTR1H-00595 from Creative biogene
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