Gene Symbol | NFS1 |
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Entrez Gene | 9054 |
Alt Symbol | HUSSY-08, IscS, NIFS |
Species | Human |
Gene Type | protein-coding |
Description | NFS1 cysteine desulfurase |
Other Description | NFS1 nitrogen fixation 1 homolog|cysteine desulfurase, mitochondrial|nitrogen fixation 1 (S. cerevisiae, homolog)|nitrogen-fixing bacteria S-like protein |
Swissprots | F5GYK5 E1P5R8 B4DXK9 B3KMA5 Q9Y481 Q6P0L8 Q9NTZ5 Q9Y697 |
Accessions | CAB87612 EAW76170 EAW76171 EAW76172 Q9Y697 AF097025 AAD09187 AJ010952 CAA09424 AK001265 AK001470 BAG50917 AK056242 BAG51655 AK091049 AK223239 BAD96959 AK295215 BAG58209 AK297969 BAG60279 AK301969 BAG63382 AK302023 BAG63421 AK312293 BAG35220 BC018471 AAH18471 BC065560 AAH65560 DA082829 HQ448113 ADQ32594 JF432612 ADZ15829 R16676 NM_001198989 NP_001185918 NM_021100 NP_066923 NR_037570 NM_181679 |
Function | Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. {ECO:0000269|PubMed:18650437}. |
Subcellular Location | Isoform Mitochondrial: Mitochondrion. |
Tissue Specificity | Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas. |
Top Pathways | Sulfur relay system, Thiamine metabolism |
NFS1 CRISPR/Cas9 KO Plasmid (h) - sc-403102 from Santa Cruz Biotechnology
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NFS1 HDR Plasmid (h) - sc-403102-HDR from Santa Cruz Biotechnology
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NFS1 Double Nickase Plasmid (h) - sc-403102-NIC from Santa Cruz Biotechnology
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NFS1 Double Nickase Plasmid (h2) - sc-403102-NIC-2 from Santa Cruz Biotechnology
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NFS1 CRISPR Activation Plasmid (h) - sc-403102-ACT from Santa Cruz Biotechnology
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NFS1 CRISPR Activation Plasmid (h2) - sc-403102-ACT-2 from Santa Cruz Biotechnology
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NFS1 Lentiviral Activation Particles (h) - sc-403102-LAC from Santa Cruz Biotechnology
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NFS1 Lentiviral Activation Particles (h2) - sc-403102-LAC-2 from Santa Cruz Biotechnology
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NFS1 siRNA (h) - sc-75911 from Santa Cruz Biotechnology
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NFS1 shRNA Plasmid (h) - sc-75911-SH from Santa Cruz Biotechnology
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NFS1 shRNA (h) Lentiviral Particles - sc-75911-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15261 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07429 from Sigma-Aldrich
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NFS1 siRNA (Human) - CRH5975 from Cohesion Biosciences
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shRNA set against Human NFS1 (NM_021100.4) - SHH351984 from Creative biogene
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Human NFS1 siRNA - orb266477 from Biorbyt
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NFS1 shRNA Plasmid (Human) - CHH5975 from Cohesion Biosciences
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NFS1 miRNA 3'UTR clone - MiUTR3H-06014 from Creative biogene
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