| Gene Symbol |
MMS22L
|
| Entrez Gene |
253714
|
| Alt Symbol |
C6orf167, dJ39B17.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MMS22-like, DNA repair protein
|
| Other Description |
protein MMS22-like
|
| Swissprots |
D6RBQ4 Q5THT2 E1P529 Q68D32 Q68CQ6 D6R9Y8 Q6ZRQ5
|
| Accessions |
CCF82070 CDI30205 EAW48494 EAW48495 EAW48496 Q6ZRQ5 AK128060 BAC87254 BC110860 BC142948 BC160006 AAI60006 BX538214 CR749603 CAH18398 CR749822 CAH18682 XM_006715430 XP_006715493 XM_006715432 XP_006715495 XM_011535670 XP_011533972 XM_011535671 XP_011533973 XM_011535672 XP_011533974 XM_011535673 XP_011533975 XM_011535674 XP_011533976 XM_011535675 XP_011533977 XM_011535676 XP_011533978 XM_011535677 XP_011533979 XM_011535678 XP_011533980 XM_011535679 XP_011533981 XM_011535680 XP_011533982 XM_011535681 XP_011533983 XR_942376 NM_198468 NP_940870
|
| Function |
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
|