Gene Symbol | MMS22L |
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Entrez Gene | 253714 |
Alt Symbol | C6orf167, dJ39B17.2 |
Species | Human |
Gene Type | protein-coding |
Description | MMS22-like, DNA repair protein |
Other Description | protein MMS22-like |
Swissprots | D6RBQ4 Q5THT2 E1P529 Q68D32 Q68CQ6 D6R9Y8 Q6ZRQ5 |
Accessions | CCF82070 CDI30205 EAW48494 EAW48495 EAW48496 Q6ZRQ5 AK128060 BAC87254 BC110860 BC142948 BC160006 AAI60006 BX538214 CR749603 CAH18398 CR749822 CAH18682 XM_006715430 XP_006715493 XM_006715432 XP_006715495 XM_011535670 XP_011533972 XM_011535671 XP_011533973 XM_011535672 XP_011533974 XM_011535673 XP_011533975 XM_011535674 XP_011533976 XM_011535675 XP_011533977 XM_011535676 XP_011533978 XM_011535677 XP_011533979 XM_011535678 XP_011533980 XM_011535679 XP_011533981 XM_011535680 XP_011533982 XM_011535681 XP_011533983 XR_942376 NM_198468 NP_940870 |
Function | Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks. |
C6orf167 CRISPR/Cas9 KO Plasmid (h) - sc-408097 from Santa Cruz Biotechnology
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C6orf167 HDR Plasmid (h) - sc-408097-HDR from Santa Cruz Biotechnology
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C6orf167 Double Nickase Plasmid (h) - sc-408097-NIC from Santa Cruz Biotechnology
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C6orf167 Double Nickase Plasmid (h2) - sc-408097-NIC-2 from Santa Cruz Biotechnology
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C6orf167 CRISPR Activation Plasmid (h) - sc-408097-ACT from Santa Cruz Biotechnology
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C6orf167 CRISPR Activation Plasmid (h2) - sc-408097-ACT-2 from Santa Cruz Biotechnology
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C6orf167 Lentiviral Activation Particles (h) - sc-408097-LAC from Santa Cruz Biotechnology
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C6orf167 Lentiviral Activation Particles (h2) - sc-408097-LAC-2 from Santa Cruz Biotechnology
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C6orf167 siRNA (h) - sc-95116 from Santa Cruz Biotechnology
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C6orf167 shRNA Plasmid (h) - sc-95116-SH from Santa Cruz Biotechnology
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C6orf167 shRNA (h) Lentiviral Particles - sc-95116-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU104371 from Sigma-Aldrich
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MISSION® esiRNA - EHU046031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14442 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14442 from Sigma-Aldrich
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MMS22L siRNA (Human) - CRJ6650 from Cohesion Biosciences
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shRNA set against Human MMS22L (NM_198468.2) - SHH343172 from Creative biogene
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MMS22L shRNA Plasmid (Human) - CHJ6650 from Cohesion Biosciences
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MMS22L miRNA 3'UTR clone - MiUTR1H-01454 from Creative biogene
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