| Gene Symbol |
CACNA2D2
|
| Entrez Gene |
9254
|
| Alt Symbol |
CACNA2D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, alpha 2/delta subunit 2
|
| Other Description |
alpha 2 delta calcium channel subunit|gene 26|voltage-dependent calcium channel subunit alpha-2/delta-2|voltage-gated calcium channel subunit alpha-2/delta-2
|
| Swissprots |
Q9NY47 Q9UEW0 Q9NY48 A7MD15 Q9Y268
|
| Accessions |
EAW65118 EAW65119 EAW65120 EAW65121 Q9NY47 AB011130 BAA25484 AF040709 AAC70914 AF042792 AAB96913 AF042793 AAB96914 AJ251367 CAB86192 AJ251368 CAB86193 AK074820 AK310138 AW451435 AW952467 BC152438 AAI52439 BF373910 DA760583 XM_005265581 XP_005265638 XM_011534242 XP_011532544 XM_011534243 XP_011532545 XM_011534244 XP_011532546 NM_001005505 NP_001005505 NM_001174051 NP_001167522 NM_001291101 NP_001278030 NM_006030 NP_006021
|
| Function |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.
|
| Tissue Specificity |
Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269|PubMed:10766861, ECO:0000269|PubMed:11687876, ECO:0000269|PubMed:9880589}.
|
| Top Pathways |
MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|