CACNA2D2
| Gene Symbol | CACNA2D2 |
|---|---|
| Entrez Gene | 9254 |
| Alt Symbol | CACNA2D |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
| Other Description | alpha 2 delta calcium channel subunit|gene 26|voltage-dependent calcium channel subunit alpha-2/delta-2|voltage-gated calcium channel subunit alpha-2/delta-2 |
| Swissprots | Q9NY47 Q9UEW0 Q9NY48 A7MD15 Q9Y268 |
| Accessions | EAW65118 EAW65119 EAW65120 EAW65121 Q9NY47 AB011130 BAA25484 AF040709 AAC70914 AF042792 AAB96913 AF042793 AAB96914 AJ251367 CAB86192 AJ251368 CAB86193 AK074820 AK310138 AW451435 AW952467 BC152438 AAI52439 BF373910 DA760583 XM_005265581 XP_005265638 XM_011534242 XP_011532544 XM_011534243 XP_011532545 XM_011534244 XP_011532546 NM_001005505 NP_001005505 NM_001174051 NP_001167522 NM_001291101 NP_001278030 NM_006030 NP_006021 |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}. |
| Tissue Specificity | Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269|PubMed:10766861, ECO:0000269|PubMed:11687876, ECO:0000269|PubMed:9880589}. |
| Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Cacna2d2 CRISPR/Cas9 KO Plasmid (h) - sc-416592 from Santa Cruz Biotechnology
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Cacna2d2 HDR Plasmid (h) - sc-416592-HDR from Santa Cruz Biotechnology
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Cacna2d2 Double Nickase Plasmid (h) - sc-416592-NIC from Santa Cruz Biotechnology
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Cacna2d2 Double Nickase Plasmid (h2) - sc-416592-NIC-2 from Santa Cruz Biotechnology
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Cacna2d2 CRISPR Activation Plasmid (h) - sc-416592-ACT from Santa Cruz Biotechnology
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Cacna2d2 CRISPR Activation Plasmid (h2) - sc-416592-ACT-2 from Santa Cruz Biotechnology
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Cacna2d2 Lentiviral Activation Particles (h) - sc-416592-LAC from Santa Cruz Biotechnology
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Cacna2d2 Lentiviral Activation Particles (h2) - sc-416592-LAC-2 from Santa Cruz Biotechnology
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Cacna2d2 siRNA (h) - sc-45522 from Santa Cruz Biotechnology
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Cacna2d2 shRNA Plasmid (h) - sc-45522-SH from Santa Cruz Biotechnology
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Cacna2d2 shRNA (h) Lentiviral Particles - sc-45522-V from Santa Cruz Biotechnology
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CACNA2D2 RNAi - H00009254-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5267 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5267 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10575 from Sigma-Aldrich
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CACNA2D2 siRNA (Human) - CRH6127 from Cohesion Biosciences
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CACNA2D2 RNAi - H00009254-R02 from Novus Biologicals
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CACNA2D2 - MBS8214411 from MyBioSource
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shRNA set against Human Cacna2d2 (NM_006030.2) - SHH253381 from Creative biogene
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shRNA set against Human CACNA2D2(NM_001005505.1) - SHG131369 from Creative biogene
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shRNA set against Human CACNA2D2(NM_006030.2) - SHG131515 from Creative biogene
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Human CACNA2D2 siRNA - orb266629 from Biorbyt
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CACNA2D2 shRNA Plasmid (Human) - CHH6127 from Cohesion Biosciences
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CACNA2D2 miRNA 3'UTR clone - MiUTR1H-01600 from Creative biogene
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