MEF2C

Gene Symbol	MEF2C
Entrez Gene	4208
Alt Symbol	C5DELq14.3, DEL5q14.3
Species	Human
Gene Type	protein-coding
Description	myocyte enhancer factor 2C
Other Description	MADS box transcription enhancer factor 2, polypeptide C|myocyte-specific enhancer factor 2C
Swissprots	D7F7N5 C9JMZ0 F8W7V7 Q06413
Accessions	CAC69373 EAW95961 EAW95962 EAW95963 EAW95964 EAW95965 EAW95966 EAW95967 EAW95968 Q06413 AK307883 AK312472 BAG35378 AL833268 AL833274 AW191949 BC026341 BC152784 AAI52785 BC156603 AAI56604 BP231922 DA494302 DA516520 DC318557 DC377336 DC377710 EU446634 ABZ92163 EU832832 ACE87843 FM163484 CAQ57795 FM180475 CAQ86609 GQ129219 ACT64353 GQ129221 ACT64355 GQ129392 ACT64526 GQ129393 ACT64527 L08895 AAA59578 S57212 AAB25838 XM_005248511 XP_005248568 XM_006714618 XP_006714681 XM_006714619 XP_006714682 XM_006714625 XP_006714688 XM_011543396 XP_011541698 XM_011543397 XP_011541699 XM_011543398 XP_011541700 XM_011543399 XP_011541701 XM_011543400 XP_011541702 XM_011543401 XP_011541703 XM_011543402 XP_011541704 XM_011543403 XP_011541705 XM_011543404 XP_011541706 XM_011543405 XP_011541707 NM_001131005 NP_001124477 NM_001193347 NP_001180276 NM_001193348 NP_001180277 NM_001193349 NP_001180278 NM_001193350 NP_001180279 NM_001308002 NP_001294931 NM_002397 NP_002388
Function	Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isofo
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in brain and skeletal muscle. {ECO:0000269|PubMed:9798649}.
Top Pathways	MAPK signaling pathway, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MEF2C (D80C1) XP ® Rabbit mAb - 5030 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D80C1

MEF2C Antibody - 9792 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

MEF-2C (F-10) - sc-365862 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MEF-2C (E-17) - sc-13266 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEF-2C (C-17) - sc-13268 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p-MEF-2C (Thr 300) - sc-130201 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-MEF2C [EPR1452(N)] antibody - ab191428 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1452(N)

Anti-MEF2C (phospho S387) antibody - ab111576 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C (phospho S396) antibody - ab78888 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C antibody - ab79436 from Abcam Host Rabbit Clonality Polyclonal

Anti-MEF2C antibody - ab43796 from Abcam Prices $378.00 Sizes 100 µl Host Mouse Clonality Polyclonal

Anti-MEF2C antibody - ab65252 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C antibody - ab65254 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C antibody - ab70961 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C antibody [4B10] - ab118406 from Abcam Prices $385.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4B10

Anti-MEF2C antibody [6H2G2] - ab140659 from Abcam Prices $384.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6H2G2

Anti-MEF2C Antibody (clone 1B6) - LS-C172866 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1B6

Anti-MEF2C Antibody (phospho-Ser396) - LS-C335769 from LifeSpan Bioscience Prices $285.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C Antibody (clone 2F2) - LS-C172614 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2F2

Anti-MEF2C Antibody (aa406-419) - LS-C312968 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MEF2C Antibody (clone 2D2) - LS-C337280 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2D2

Anti-MEF2C Antibody (clone 1H5) - LS-C337296 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1H5

Anti-MEF2C Antibody (clone 4F7) - LS-C172812 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4F7

Anti-MEF2C Antibody (clone 4G8) - LS-C337294 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4G8

Anti-MEF2C Antibody (Thr20, AP) - LS-C279797 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Search more