MEF2C

Gene Symbol MEF2C
Entrez Gene 4208
Alt Symbol C5DELq14.3, DEL5q14.3
Species Human
Gene Type protein-coding
Description myocyte enhancer factor 2C
Other Description MADS box transcription enhancer factor 2, polypeptide C|myocyte-specific enhancer factor 2C
Swissprots D7F7N5 C9JMZ0 F8W7V7 Q06413
Accessions CAC69373 EAW95961 EAW95962 EAW95963 EAW95964 EAW95965 EAW95966 EAW95967 EAW95968 Q06413 AK307883 AK312472 BAG35378 AL833268 AL833274 AW191949 BC026341 BC152784 AAI52785 BC156603 AAI56604 BP231922 DA494302 DA516520 DC318557 DC377336 DC377710 EU446634 ABZ92163 EU832832 ACE87843 FM163484 CAQ57795 FM180475 CAQ86609 GQ129219 ACT64353 GQ129221 ACT64355 GQ129392 ACT64526 GQ129393 ACT64527 L08895 AAA59578 S57212 AAB25838 XM_005248511 XP_005248568 XM_006714618 XP_006714681 XM_006714619 XP_006714682 XM_006714625 XP_006714688 XM_011543396 XP_011541698 XM_011543397 XP_011541699 XM_011543398 XP_011541700 XM_011543399 XP_011541701 XM_011543400 XP_011541702 XM_011543401 XP_011541703 XM_011543402 XP_011541704 XM_011543403 XP_011541705 XM_011543404 XP_011541706 XM_011543405 XP_011541707 NM_001131005 NP_001124477 NM_001193347 NP_001180276 NM_001193348 NP_001180277 NM_001193349 NP_001180278 NM_001193350 NP_001180279 NM_001308002 NP_001294931 NM_002397 NP_002388
Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isofo
Subcellular Location Nucleus.
Tissue Specificity Expressed in brain and skeletal muscle. {ECO:0000269|PubMed:9798649}.
Top Pathways MAPK signaling pathway, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Transcriptional misregulation in cancer

MEF-2C CRISPR/Cas9 KO Plasmid (h) - sc-416594 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C HDR Plasmid (h) - sc-416594-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C Double Nickase Plasmid (h) - sc-416594-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C Double Nickase Plasmid (h2) - sc-416594-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C CRISPR Activation Plasmid (h) - sc-416594-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C CRISPR Activation Plasmid (h2) - sc-416594-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C Lentiviral Activation Particles (h) - sc-416594-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C Lentiviral Activation Particles (h2) - sc-416594-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEF-2C siRNA (h) - sc-38062 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEF-2C shRNA Plasmid (h) - sc-38062-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEF-2C shRNA (h) Lentiviral Particles - sc-38062-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU113621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13188 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13188 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MEF2C siRNA (Human) - CRH2860 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MEF2C RNAi - H00004208-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MEF2C (NM_002397.4) - SHH340199 from Creative biogene

Category siRNA
Species Reactivities Human

Human MEF2C siRNA - orb263362 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MEF2C shRNA Plasmid (Human) - CHH2860 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MEF2C miRNA 3'UTR clone - MiUTR4H-TG11719 from Creative biogene

Species Reactivities Human
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