PIK3CD

Gene Symbol	PIK3CD
Entrez Gene	5293
Alt Symbol	APDS, IMD14, P110DELTA, PI3K, p110D
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Other Description	PI3-kinase p110 subunit delta|PI3Kdelta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform|phosphoinositide-3-kinase C|phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta|ptdIns-3-kinase subunit p110-delta
Swissprots	Q5SR49 G1FFP1 O00329 O15445 A6NCG0
Accessions	EAW71622 EAW71623 EAW71624 EAW71625 EAW71626 EAW71627 O00329 AB208835 BAD92072 AK303425 BAG64476 AK314191 BAG36870 BC030263 BC132919 AAI32920 BC132921 AAI32922 BC144264 AAI44265 BC150297 AAI50298 CN313981 DQ263594 ABB83814 DQ263595 ABB83815 DQ263596 ABB83816 JN190435 AEK81610 U57843 AAB53966 U86453 AAC25677 W30913 Y10055 CAA71149 XM_005263473 XP_005263530 XM_006710686 XP_006710749 XM_006710687 XP_006710750 XM_006710688 XP_006710751 XM_006710689 XP_006710752 XM_006710690 XP_006710753 XM_011541581 XP_011539883 XM_011541582 XP_011539884 XM_011541583 XP_011539885 XR_946667 NM_005026 NP_005017
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell recepto
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22020336}.
Tissue Specificity	Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes. {ECO:0000269|PubMed:22020336}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Active human PI 3 Kinase p110 delta full length protein - ab68613 from Abcam Category Protein Prices $239.00 Sizes 1 µg Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase p110 delta peptide - ab93748 from Abcam Category Peptide

Human PI 3 Kinase p110 delta protein fragment - ab159129 from Abcam Category Protein Source Wheat germ Species Human

PIK3CD-Center-Y524-Blocking-peptide - BP19523c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-PIK3CDY485-Antibody-Blocking-peptide - BP3493a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-PIK3CDY524-Antibody-Blocking-peptide - BP3463a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PI3KCD-Antibody-C-term-Blocking-Peptide - BP8020a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI 3-Kinase delta GST tag protein - orb85160 from Biorbyt Category Protein Prices $485.00 Sizes 10 μg Source O00329 Species Bacteria

PIK3CD - H00005293-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIK3CD - H00005293-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIK3CD fusion protein - ag16326 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PIK3CD fusion protein - ag16713 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PI3 kinase (p110d/p85a), Active Human Recombinant Protein - GWB-FE3672 from Genway Biotech Category Protein Prices $584.00 Sizes 20 µg Species Human

Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged - PIK3CD-1896H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human PIK3CD, GST-tagged - PIK3CD-52H from Creative Biomart Category Protein Source Sf9 insect cells .

Recombinant Human PIK3CD - PIK3CD-29587TH from Creative Biomart Category Protein

Recombinant Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) - RPJ832Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

PI3 Kinase (p110δ/p85α) Protein, active, 250 µg - 14-604M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-604) and in bulk (cat# 14-604-K) Source Coexpressed by baculovirus in Sf21 insect cells

PI3K p110 delta Blocking Peptide - CBP1889 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PI3K p110δ Peptide - BS60441P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) - RPJ832Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(PIK3CD) ,partial - CSB-YP018000HU CSB-EP018000HU CSB-BP018000HU CSB-MP018000HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD), partial, Recombinant Protein - MBS1112148 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Phosphoinositide 3 Kinase, p85 alpha, p110 delta, Recombinant Protein - MBS635734 from MyBioSource Category Protein Prices $490.00, $870.00 Sizes 1 µg, 5 µg Source Sf9 insect cells

Phosphoinositide 3 Kinase, p85 alpha, p110 delta, Recombinant Protein - MBS636922 from MyBioSource Category Protein Prices $695.00 Sizes 20 µg Source Baculovirus infected Sf9 cells

Search more