| Gene Symbol |
PIK3CD
|
| Entrez Gene |
5293
|
| Alt Symbol |
APDS, IMD14, P110DELTA, PI3K, p110D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
|
| Other Description |
PI3-kinase p110 subunit delta|PI3Kdelta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform|phosphoinositide-3-kinase C|phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta|ptdIns-3-kinase subunit p110-delta
|
| Swissprots |
Q5SR49 G1FFP1 O00329 O15445 A6NCG0
|
| Accessions |
EAW71622 EAW71623 EAW71624 EAW71625 EAW71626 EAW71627 O00329 AB208835 BAD92072 AK303425 BAG64476 AK314191 BAG36870 BC030263 BC132919 AAI32920 BC132921 AAI32922 BC144264 AAI44265 BC150297 AAI50298 CN313981 DQ263594 ABB83814 DQ263595 ABB83815 DQ263596 ABB83816 JN190435 AEK81610 U57843 AAB53966 U86453 AAC25677 W30913 Y10055 CAA71149 XM_005263473 XP_005263530 XM_006710686 XP_006710749 XM_006710687 XP_006710750 XM_006710688 XP_006710751 XM_006710689 XP_006710752 XM_006710690 XP_006710753 XM_011541581 XP_011539883 XM_011541582 XP_011539884 XM_011541583 XP_011539885 XR_946667 NM_005026 NP_005017
|
| Function |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell recepto
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22020336}.
|
| Tissue Specificity |
Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes. {ECO:0000269|PubMed:22020336}.
|
| Top Pathways |
Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway
|