| Gene Symbol |
ACE2
|
| Entrez Gene |
59272
|
| Alt Symbol |
ACEH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
angiotensin I converting enzyme 2
|
| Other Description |
ACE-related carboxypeptidase|angiotensin I converting enzyme (peptidyl-dipeptidase A) 2|angiotensin-converting enzyme 2|angiotensin-converting enzyme homolog|metalloprotease MPROT15|peptidyl-dipeptidase A
|
| Swissprots |
Q9NRA7 Q9UFZ6 C7ECU1 Q86WT0 Q6UWP0 Q9BYF1
|
| Accessions |
AAO25651 CAC18991 CAD35458 CAD37288 EAW98891 EAW98892 Q9BYF1 AB046569 BAB40370 AB193259 BAD99266 AB193260 BAD99267 AF241254 AAF78220 AF291820 AAF99721 AK026461 AK315144 BAG37592 AL110224 CAB53682 AY358714 AAQ89076 AY623811 AAT45083 BC032938 BC039902 AAH39902 BC048094 AAH48094 BC048144 BC059378 GQ262784 ACT66268 XM_011545549 XP_011543851 XM_011545550 XP_011543852 XM_011545551 XP_011543853 XM_011545552 XP_011543854 NM_021804 NP_068576
|
| Function |
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:24227843}.
|
| Subcellular Location |
Processed angiotensin-converting enzyme 2: Secreted.
|
| Tissue Specificity |
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15141377, ECO:0000269|PubMed:15231706, ECO:0000269|PubMed:15671045}.
|
| Top Pathways |
Protein digestion and absorption, Renin-angiotensin system
|