| Gene Symbol | CDK1 |
|---|---|
| Entrez Gene | 983 |
| Alt Symbol | CDC2, CDC28A, P34CDC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 1 |
| Other Description | cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase |
| Swissprots | O60764 P06493 A8K7C4 C9J497 |
| Accessions | AAM34793 EAW54204 EAW54205 EAW54206 EAW54207 EAW54208 EAW54209 EAW54210 P06493 AA459484 AK291939 BAF84628 AK295741 BAH12172 AM392583 CAL37461 AM393047 CAL37925 AM393287 CAL38165 AM393726 CAL38602 AW976143 BC014563 AAH14563 BC107750 AAI07751 BF685285 BG723076 BT007004 AAP35650 BU633268 CR933728 CAI46271 D88357 BAA26001 DA823877 X05360 CAA28963 Y00272 CAA68376 XM_005270303 XP_005270360 XM_006718082 XP_006718145 NM_001170406 NP_001163877 NM_001170407 NP_001163878 NM_001786 NP_001777 NM_033379 NP_203698 NM_001130829 |
| Function | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, be |
| Subcellular Location | Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage. |
| Tissue Specificity | Isoform 2 is found in breast cancer tissues. |
| Top Pathways | Cell cycle, p53 signaling pathway, Gap junction, Progesterone-mediated oocyte maturation, Oocyte meiosis |