CDK1

Gene Symbol CDK1
Entrez Gene 983
Alt Symbol CDC2, CDC28A, P34CDC2
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase 1
Other Description cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
Swissprots O60764 P06493 A8K7C4 C9J497
Accessions AAM34793 EAW54204 EAW54205 EAW54206 EAW54207 EAW54208 EAW54209 EAW54210 P06493 AA459484 AK291939 BAF84628 AK295741 BAH12172 AM392583 CAL37461 AM393047 CAL37925 AM393287 CAL38165 AM393726 CAL38602 AW976143 BC014563 AAH14563 BC107750 AAI07751 BF685285 BG723076 BT007004 AAP35650 BU633268 CR933728 CAI46271 D88357 BAA26001 DA823877 X05360 CAA28963 Y00272 CAA68376 XM_005270303 XP_005270360 XM_006718082 XP_006718145 NM_001170406 NP_001163877 NM_001170407 NP_001163878 NM_001786 NP_001777 NM_033379 NP_203698 NM_001130829
Function Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, be
Subcellular Location Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage.
Tissue Specificity Isoform 2 is found in breast cancer tissues.
Top Pathways Cell cycle, p53 signaling pathway, Gap junction, Progesterone-mediated oocyte maturation, Oocyte meiosis

PathScan® Phospho-cdc2 (Tyr15) Sandwich ELISA Kit - 7176 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 2: The relationship between protein concentration of lysates from lambda phosphatase and IL-4 treated HeLa cells and kit assay optical density reading. HeLa cells (80% confluent) were treated with human IL-4 for 10 minutes (100 ng/ml).

PathScan® Phospho-cdc2 (Tyr15) Sandwich ELISA Antibody Pair - 7838 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)
The relationship between protein concentration of lysates from λ phosphatase-treated and IL-4-treated HeLa cells and the absorbance at 450 nm using PathScan ® Phospho-cdc2 (Tyr15) Sandwich ELISA Antibody Pair #7838 is shown. HeLa cells (80% confluent) were treated with human IL-4 for 10 minutes (100 ng/ml) at 37°C and then lysed.

PathScan® Phospho-cdc2 (Thr161) Sandwich ELISA Kit - 7184 from Cell Signaling Technology

Category ELISA Kit

Human CDK1 / CDC2 ELISA Kit (Sandwich ELISA) - LS-F5060 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.068 ng/ml
Range 0.156-10 ng/ml

Mouse/Human/Rat CDK1 / CDC2 ELISA Kit (Cell-Based ELISA) - LS-F1874 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-CDK1 / CDC2 (Thr161) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1468 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-CDK1 / CDC2 (Tyr15) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1469 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Rabbit anti-CDK1 Antibody, Affinity Purified - PLA0287 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Human CDK1 ELISA Kit - abx151011 from Abbexa

Category ELISA Kit
Sensitivity 0.068 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human Cyclin-Dependent Kinase 1 ELISA Kit - abx053445 from Abbexa

Category ELISA Kit
Sensitivity 12.5 pg/ml
Range 40 pg/ml - 2000 pg/ml

Cyclin Dependent Kinase 1, CDK1, Human, ELISA Kit - E-EL-H2321 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Cyclin-dependent kinase 1, CDK1, Human, ELISA Kit - E1888h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Cyclin Dependent Kinase 1, CDK1, Rabbit, ELISA Kit - E-EL-RB1219 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cyclin Dependent Kinase 1, CDK1, Chicken, ELISA Kit - E-EL-Ch1662 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Cyclin Dependent Kinase 1, CDK1, Porcine, ELISA Kit - E-EL-P1296 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cyclin Dependent Kinase 1, CDK1, Sheep, ELISA Kit - E-EL-S0404 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Cyclin Dependent Kinase 1, CDK1, Monkey, ELISA Kit - E-EL-MK0246 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human CDK-1 ELISA Kit - HC0728 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine CDK-1 ELISA Kit - AC0728 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine Pertussis virus IgA ELSA KIT ELISA Kit - AP0014 from NeoScientific

Category ELISA Kit
Prices $300.00, $480.00
Sizes 100 µl, 200 µl

Anserine Pertussis virus IgM ELSA KIT ELISA Kit - AP0015 from NeoScientific

Category ELISA Kit
Prices $300.00, $480.00
Sizes 100 µl, 200 µl

Anserine Pertussis virus IgD ELSA KIT ELISA Kit - AP0016 from NeoScientific

Category ELISA Kit
Prices $300.00, $480.00
Sizes 100 µg, 200 µg
Western blot analysis of extracts from HeLa cells, using Phospho-CDK1-Y15 antibody.

Cyclin-dependent kinase 1 (CDK1) , ELISA Kit - MBS707090 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 11.72 pg/ml.
Range 46.88 pg/ml -3000 pg/ml.

CDC2 Colorimetric Cell-Based ELISA Kit - CB5124 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

CDC2 (Phospho-Thr161) Colorimetric Cell-Based ELISA Kit - CBP1511 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells
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