CDK1

Gene Symbol	CDK1
Entrez Gene	983
Alt Symbol	CDC2, CDC28A, P34CDC2
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 1
Other Description	cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
Swissprots	O60764 P06493 A8K7C4 C9J497
Accessions	AAM34793 EAW54204 EAW54205 EAW54206 EAW54207 EAW54208 EAW54209 EAW54210 P06493 AA459484 AK291939 BAF84628 AK295741 BAH12172 AM392583 CAL37461 AM393047 CAL37925 AM393287 CAL38165 AM393726 CAL38602 AW976143 BC014563 AAH14563 BC107750 AAI07751 BF685285 BG723076 BT007004 AAP35650 BU633268 CR933728 CAI46271 D88357 BAA26001 DA823877 X05360 CAA28963 Y00272 CAA68376 XM_005270303 XP_005270360 XM_006718082 XP_006718145 NM_001170406 NP_001163877 NM_001170407 NP_001163878 NM_001786 NP_001777 NM_033379 NP_203698 NM_001130829
Function	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, be
Subcellular Location	Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage.
Tissue Specificity	Isoform 2 is found in breast cancer tissues.
Top Pathways	Cell cycle, p53 signaling pathway, Gap junction, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDK1 293 Cell Lysate - 405011 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CDK1 293 Cell Lysate - 400661 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CDC2/CDK1 Overexpression Lysate (Native) - NBL1-08991 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cdc2 p34 (h2): 293 Lysate - sc-128282 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Cdc2 p34 (h5): 293T Lysate - sc-158363 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CDK1 Over-expression Lysate Product - GWB-FB3459 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CDK1 Over-expression Lysate Product - GWB-1CE9F5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human CDC2 Kinase / CDK1 Insect Cell Lysate (WB positive control) - 10739-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

CDC2/CDK1 Overexpression Lysate (Denatured) - H00000983-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human CDK1 Knockdown Stable Cell Line - CSC-DC002857 from Creative biogene Category Cell Line Species Human

Search more