Gene Symbol | APBA3 |
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Entrez Gene | 9546 |
Alt Symbol | MGC:15815, X11L2, mint3 |
Species | Human |
Gene Type | protein-coding |
Description | amyloid beta (A4) precursor protein-binding, family A, member 3 |
Other Description | X11-like 2 protein|adapter protein X11gamma|amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)|amyloid beta A4 precursor protein-binding family A member 3|mint-3|neuron-specific X11L2 protein|neuronal munc18-1-interacting protein 3|phosphotyrosine-binding/-interacting domain (PTB)-bearing protein |
Swissprots | Q9UPZ2 O96018 O60483 |
Accessions | AAC72275 BAA83094 BAA83517 EAW69290 EAW69291 O96018 AB021638 BAA74430 AB209603 BAD92840 AF029110 AAC17979 BC008338 BC086306 AAH86306 BG938716 BI910038 BM977984 BQ707748 XM_006722950 XP_006723013 XM_006722951 XP_006723014 NM_004886 NP_004877 |
Function | May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269|PubMed:19726677}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000269|PubMed:19726677}. |
Tissue Specificity | Expressed in all tissues examined with lower levels in brain and testis. |
X11γ CRISPR/Cas9 KO Plasmid (h) - sc-411292 from Santa Cruz Biotechnology
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X11γ HDR Plasmid (h) - sc-411292-HDR from Santa Cruz Biotechnology
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X11γ Double Nickase Plasmid (h) - sc-411292-NIC from Santa Cruz Biotechnology
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X11γ Double Nickase Plasmid (h2) - sc-411292-NIC-2 from Santa Cruz Biotechnology
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X11γ CRISPR Activation Plasmid (h) - sc-411292-ACT from Santa Cruz Biotechnology
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X11γ CRISPR Activation Plasmid (h2) - sc-411292-ACT-2 from Santa Cruz Biotechnology
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X11γ Lentiviral Activation Particles (h) - sc-411292-LAC from Santa Cruz Biotechnology
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X11γ Lentiviral Activation Particles (h2) - sc-411292-LAC-2 from Santa Cruz Biotechnology
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X11γ siRNA (h) - sc-36847 from Santa Cruz Biotechnology
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X11γ shRNA Plasmid (h) - sc-36847-SH from Santa Cruz Biotechnology
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X11γ shRNA (h) Lentiviral Particles - sc-36847-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3306 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3306 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01351 from Sigma-Aldrich
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APBA3 siRNA (Human) - CRH6349 from Cohesion Biosciences
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APBA3 - MBS8232563 from MyBioSource
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shRNA set against Human APBA3 (NM_004886.3) - SHH238042 from Creative biogene
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shRNA set against Human APBA3(NM_004886.3) - SHG032473 from Creative biogene
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APBA3 shRNA Plasmid (Human) - CHH6349 from Cohesion Biosciences
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APBA3 miRNA 3'UTR clone - MiUTR1H-00454 from Creative biogene
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