Gene Symbol | MTR |
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Entrez Gene | 4548 |
Alt Symbol | HMAG, MS, cblG |
Species | Human |
Gene Type | protein-coding |
Description | 5-methyltetrahydrofolate-homocysteine methyltransferase |
Other Description | 5-methyltetrahydrofolate-homocysteine methyltransferase 1|cobalamin-dependent methionine synthase|methionine synthase|vitamin-B12 dependent methionine synthase |
Swissprots | Q99713 B7ZLW7 A9Z1W4 Q99707 Q99723 B9EGF7 A1L4N8 |
Accessions | EAW70066 EAW70067 Q99707 AK090487 AK125206 AK127317 AK294270 BAG57561 AK299904 BAG61745 AK307390 AY429553 BC015894 BC067276 BC130616 AAI30617 BC136440 AAI36441 BC144095 AAI44096 BC144097 AAI44098 BC144098 BX641132 CAE46059 CB241165 DC377743 U71285 AAC51188 U73338 AAB39704 U75743 AAB58906 XM_005273141 XP_005273198 XM_006711769 XP_006711832 XM_006711770 XP_006711833 XM_011544193 XP_011542495 XM_011544194 XP_011542496 NM_000254 NP_000245 NM_001291939 NP_001278868 NM_001291940 NP_001278869 |
Function | Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney. |
Top Pathways | Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids, One carbon pool by folate |
Human MTR peptide - ab69085 from Abcam
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Human MTR peptide - ab23154 from Abcam
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Human MTR protein fragment - ab152546 from Abcam
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MS / MTR Antibody Blocking Peptide - LS-E25212 from LifeSpan Bioscience
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MS / MTR Antibody Blocking Peptide - LS-E17535 from LifeSpan Bioscience
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Recombinant Human MTR Protein - H00004548-Q01 from Novus Biologicals
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MTR Blocking Peptide - NBP1-79285PEP from Novus Biologicals
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MTR blocking peptide - GTX89998-PEP from GeneTex
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Human MTR protein - orb246622 from Biorbyt
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Human MTR protein - orb246877 from Biorbyt
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MTR Blocking Peptide - 33R-3557 from Fitzgerald
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MTR Peptide - AC21-0034-P from Abcore
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Methionine synthase / MTR - H00004548-Q01-10 from Acris Antibodies
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Methionine synthase / MTR - H00004548-Q01-25 from Acris Antibodies
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MTR Peptide - 45-914P from ProSci
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MTR fusion protein - Ag23156 from Proteintech Group
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Recombinant 5-Methyltetrahydrofolate Homocysteine Methyltransferase (MTR) - RPG462Hu01 from Uscn Life Science Inc.
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Recombinant 5-Methyltetrahydrofolate Homocysteine Methyltransferase (MTR) - RPG462Hu01 from Cloud-clone
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Recombinant Human Methionine synthase(MTR) ,partial - CSB-YP859939HU CSB-BP859939HU CSB-MP859939HU from Cusabio
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Recombinant Human Methionine synthase(MTR) ,partial - CSB-EP859939HU from Cusabio
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MTR, Peptide - MBS426478 from MyBioSource
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MTR Peptide, Human - M34GP09906H from Creative Peptides
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MTR Recombinant Protein (OPCA02451) - OPCA02451 from Aviva Systems Biology
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MTR Recombinant Protein (OPCA03062) - OPCA03062 from Aviva Systems Biology
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MTR Recombinant Protein (OPCD05440) - OPCD05440 from Aviva Systems Biology
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