| Gene Symbol | Csnk2a1 |
|---|---|
| Entrez Gene | 12995 |
| Alt Symbol | Csnk2a1-rs4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | casein kinase 2, alpha 1 polypeptide |
| Other Description | CK II alpha|casein kinase II subunit alpha|casein kinase II, alpha 1 polypeptide|casein kinase II, alpha 1 related sequence 4 |
| Swissprots | Q60737 Q8R0X4 |
| Accessions | EDL05953 EDL05954 Q60737 AK011501 BAB27661 AK031617 BAC27481 AK042898 AK133980 AK146032 BAE26845 AK158077 BAE34350 AK162515 BC026149 AAH26149 BC058604 BC060742 AAH60742 BC069919 AAH69919 BC089343 AAH89343 BF018216 BY015187 CA322616 U17112 AAA64563 U51866 AAA96795 XM_006498657 XP_006498720 XM_011239272 XP_011237574 NM_007788 NP_031814 |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat |
| Top Pathways | Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles |