Csnk2a1

Gene Symbol	Csnk2a1
Entrez Gene	12995
Alt Symbol	Csnk2a1-rs4
Species	Mouse
Gene Type	protein-coding
Description	casein kinase 2, alpha 1 polypeptide
Other Description	CK II alpha|casein kinase II subunit alpha|casein kinase II, alpha 1 polypeptide|casein kinase II, alpha 1 related sequence 4
Swissprots	Q60737 Q8R0X4
Accessions	EDL05953 EDL05954 Q60737 AK011501 BAB27661 AK031617 BAC27481 AK042898 AK133980 AK146032 BAE26845 AK158077 BAE34350 AK162515 BC026149 AAH26149 BC058604 BC060742 AAH60742 BC069919 AAH69919 BC089343 AAH89343 BF018216 BY015187 CA322616 U17112 AAA64563 U51866 AAA96795 XM_006498657 XP_006498720 XM_011239272 XP_011237574 NM_007788 NP_031814
Function	Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat
Top Pathways	Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CK2α siRNA I (Rodent Specific) - 9400 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

casein kinase IIα CRISPR/Cas9 KO Plasmid (m) - sc-419852 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα HDR Plasmid (m) - sc-419852-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα Double Nickase Plasmid (m) - sc-419852-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα Double Nickase Plasmid (m2) - sc-419852-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα CRISPR Activation Plasmid (m) - sc-419852-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα CRISPR Activation Plasmid (m2) - sc-419852-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα Lentiviral Activation Particles (m) - sc-419852-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα Lentiviral Activation Particles (m2) - sc-419852-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

casein kinase IIα siRNA (m) - sc-29919 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

casein kinase IIα shRNA Plasmid (m) - sc-29919-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

casein kinase IIα shRNA (m) Lentiviral Particles - sc-29919-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU093681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN29308 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29308 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CSNK2A1 siRNA (Mouse) - CRM0882 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CSNK2A1 - MBS827121 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse CSNK2A1 (NM_007788.3) - SHH270525 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Csnk2a1(NM_007788.3) - SHG204055 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse CSNK2A1 siRNA - orb280358 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CSNK2A1 shRNA Plasmid (Mouse) - CHM0882 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

CSNK2A1 miRNA 3'UTR clone - MiUTR1M-03395 from Creative biogene Species Reactivities Mouse

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