Gene Symbol | ACTL6B |
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Entrez Gene | 51412 |
Alt Symbol | ACTL6, BAF53B |
Species | Human |
Gene Type | protein-coding |
Description | actin-like 6B |
Other Description | 53 kDa BRG1-associated factor B|BRG1-associated factor 53B|actin-like 6|actin-like protein 6B|actin-related protein Baf53b|arpNalpha|hArpN alpha |
Swissprots | O75421 O94805 A4D2D0 |
Accessions | AAP21874 EAL23823 EAW76502 EAW76503 EAW76504 EAW76505 O94805 AB015906 BAA74576 AF041475 AAD54678 AK314940 BAG37446 BC008582 BC020944 AAH20944 BM696009 HQ447891 ADQ32375 XR_927476 NM_016188 NP_057272 |
Function | Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multi |
Subcellular Location | Nucleus. |
ACTL6B-Over-expression-Lysate - LY14132a from Abgent, a WuXi AppTec company
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ACTL6B overexpression lysate - LY402516 from Acris Antibodies
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ACTL6B 293 Cell Lysate - 402202 from ABBIOTEC
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ACTL6B Overexpression Lysate (Native) - NBL1-07278 from Novus Biologicals
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ACTL6B Over-expression Lysate Product - GWB-621CC5 from Genway Biotech
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Panoply™ Human ACTL6B Knockdown Stable Cell Line - CSC-DC000192 from Creative biogene
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