Parp1

Gene Symbol Parp1
Entrez Gene 11545
Alt Symbol 5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1
Species Mouse
Gene Type protein-coding
Description poly (ADP-ribose) polymerase family, member 1
Other Description ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase diphtheria toxin-like 1|ADPRT 1|NAD(+) ADP-ribosyltransferase 1|msPARP|poly [ADP-ribose] polymerase 1|poly[ADP-ribose] synthase 1|poly[ADP-ribose] synthetase 1
Swissprots P11103 Q9JLX4 Q9QVQ3
Accessions EDL13152 P11103 AF126717 AAF61293 AK028042 AK030889 BAC27173 AK088679 BAC40500 AK135977 BAE22758 AK146677 BAE27352 AK152360 BAE31150 AK159433 BAE35080 AK165158 AK166104 BAE38574 AK167699 BAE39743 AK169326 BAE41080 AK195303 AK202655 AK210311 BC012041 AAH12041 X14206 CAA32421 NM_007415 NP_031441
Function Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN- gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity).
Subcellular Location Nucleus. Nucleus, nucleolus {ECO:0000250}. Note=Localizes at sites of DNA damage. {ECO:0000250}.
Tissue Specificity Widely expressed. Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult. Expressed in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269|PubMed:9642267}.
Top Pathways Base excision repair

Mouse PARP Protein - abx068631 from Abbexa

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Parp1, His tagged - Parp1-2535M from Creative Biomart

Category Protein
Source Baculovirus-Insect Cells
Species Mouse

Mouse PARP-1 / PARP Protein (His Tag) - 50753-M07B-20 from Sino Biological

Category Protein
Prices $138.00, $348.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
Species Mouse

Recombinant Poly ADP Ribose Polymerase (PARP) - RPA279Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Poly [ADP-ribose] polymerase 1(Parp1) ,partial - CSB-YP017457MO CSB-EP017457MO CSB-BP017457MO CSB-MP017457MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Poly ADP Ribose Polymerase (PARP), Recombinant Protein - MBS2018661 from MyBioSource

Category Protein
Prices $200.00, $430.00, $665.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Mouse

Poly [ADP-ribose] polymerase 1 (Parp1), partial, Recombinant Protein - MBS968487 from MyBioSource

Category Protein
Prices $1,010.00, $1,010.00, $1,240.00, $1,240.00, $1,500.00, $1,500.00, $1,960.00, $1,960.00, $1,995.00, $2,955.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse PARP-1 / PARP Protein (His tag) - PKSM040501 from Elabscience

Category Protein
Source Baculoviru
Species Mouse

Mouse PARP1 protein (His Tag) - orb139450 from Biorbyt

Category Protein
Prices $417.00, $859.00
Sizes 20 μg, 100 μg
Source Baculovirus-Insect Cells
Species Mouse

PARP1 Recombinant Protein (OPCD05990) - OPCD05990 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Mouse PARP-1 / PARP Protein (His Tag) - 50753-M07B from ABclonal

Category Protein
Prices $138.00, $348.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
Species Mouse

PARP-1 / PARP, Recombinant Protein - MBS2546804 from MyBioSource

Category Protein
Prices $375.00, $905.00
Sizes 20 µg, 100 µg
Source Baculovirus-Insect Cells
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