| Gene Symbol |
Parp1
|
| Entrez Gene |
11545
|
| Alt Symbol |
5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) polymerase family, member 1
|
| Other Description |
ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase diphtheria toxin-like 1|ADPRT 1|NAD(+) ADP-ribosyltransferase 1|msPARP|poly [ADP-ribose] polymerase 1|poly[ADP-ribose] synthase 1|poly[ADP-ribose] synthetase 1
|
| Swissprots |
P11103 Q9JLX4 Q9QVQ3
|
| Accessions |
EDL13152 P11103 AF126717 AAF61293 AK028042 AK030889 BAC27173 AK088679 BAC40500 AK135977 BAE22758 AK146677 BAE27352 AK152360 BAE31150 AK159433 BAE35080 AK165158 AK166104 BAE38574 AK167699 BAE39743 AK169326 BAE41080 AK195303 AK202655 AK210311 BC012041 AAH12041 X14206 CAA32421 NM_007415 NP_031441
|
| Function |
Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN- gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity).
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus {ECO:0000250}. Note=Localizes at sites of DNA damage. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult. Expressed in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269|PubMed:9642267}.
|
| Top Pathways |
Base excision repair
|
