| Gene Symbol |
ADGRL2
|
| Entrez Gene |
23266
|
| Alt Symbol |
CIRL2, CL2, LEC1, LPHH1, LPHN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adhesion G protein-coupled receptor L2
|
| Other Description |
calcium-independent alpha-latrotoxin receptor 2|latrophilin 2|latrophilin homolog 1|latrophilin-2|lectomedin-1
|
| Swissprots |
B1ALU5 B1ALU4 Q9UKY6 Q9UKY5 B1ALU2 B1ALT9 B1ALU0 B1ALU6 B1ALT8 Q5VX76 O94882 O95490 A5XEI2
|
| Accessions |
CAB60201 CAB60202 CAB60203 CAB60204 CAB60205 CAB60206 CAB60207 CAB60229 EAX06321 EAX06322 EAX06323 EAX06324 EAX06325 EAX06326 EAX06327 EAX06328 EAX06329 EAX06330 EAX06331 EAX06332 EAX06333 EAX06334 EAX06335 EAX06336 EAX06337 EAX06338 EAX06339 EAX06340 EAX06341 O95490 AB018329 BAA34506 AF104266 AAD54675 AF104938 AAD54676 AF104939 AAD54677 AJ131581 CAA10458 AK123422 BAG53903 AW008295 BC031321 BM983870 DQ925675 ABL59902 XM_005270666 XP_005270723 XM_005270667 XP_005270724 XM_005270668 XP_005270725 XM_005270670 XP_005270727 XM_005270673 XP_005270730 XM_006710485 XP_006710548 XM_006710488 XP_006710551 XM_006710489 XP_006710552 XM_006710490 XP_006710553 XM_006710491 XP_006710554 XM_006710493 XP_006710556 XM_006710494 XP_006710557 XM_006710497 XP_006710560 XM_011541093 XP_011539395 XM_011541094 XP_011539396 XM_011541095 XP_011539397 XM_011541096 XP_011539398 XR_946591 XR_946592 NM_001297704 NP_001284633 NM_001297705 NP_001284634 NM_001297706 NP_001284635 NM_012302 NP_036434
|
| Function |
Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. {ECO:0000269|PubMed:10030676}.
|