| Gene Symbol | C5 |
|---|---|
| Entrez Gene | 727 |
| Alt Symbol | C5D, C5a, C5b, CPAMD4, ECLZB |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 5 |
| Other Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4|C5a anaphylatoxin|anaphylatoxin C5a analog|complement C5|prepro-C5 |
| Swissprots | Q27I61 P01031 Q14CJ0 |
| Accessions | AAP13242 ABD48959 BAO02074 EAW87480 P01031 AB209031 BAD92268 AK310774 AK310780 AV682721 BC022299 BC113738 AAI13739 BC113740 AAI13741 BG533927 CB250401 M57729 AAA51925 M65134 AAA51856 S79279 AAB35171 T82068 XM_011518980 XP_011517282 XM_011518981 XP_011517283 XM_011518982 XP_011517284 NM_001735 NP_001726 |
| Function | Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Staphylococcus aureus infection, Pertussis |