Gene Symbol | C5 |
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Entrez Gene | 727 |
Alt Symbol | C5D, C5a, C5b, CPAMD4, ECLZB |
Species | Human |
Gene Type | protein-coding |
Description | complement component 5 |
Other Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4|C5a anaphylatoxin|anaphylatoxin C5a analog|complement C5|prepro-C5 |
Swissprots | Q27I61 P01031 Q14CJ0 |
Accessions | AAP13242 ABD48959 BAO02074 EAW87480 P01031 AB209031 BAD92268 AK310774 AK310780 AV682721 BC022299 BC113738 AAI13739 BC113740 AAI13741 BG533927 CB250401 M57729 AAA51925 M65134 AAA51856 S79279 AAB35171 T82068 XM_011518980 XP_011517282 XM_011518981 XP_011517283 XM_011518982 XP_011517284 NM_001735 NP_001726 |
Function | Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. |
Subcellular Location | Secreted. |
Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Staphylococcus aureus infection, Pertussis |
C5 CRISPR/Cas9 KO Plasmid (h) - sc-401533 from Santa Cruz Biotechnology
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C5 HDR Plasmid (h) - sc-401533-HDR from Santa Cruz Biotechnology
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C5 Double Nickase Plasmid (h) - sc-401533-NIC from Santa Cruz Biotechnology
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C5 Double Nickase Plasmid (h2) - sc-401533-NIC-2 from Santa Cruz Biotechnology
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C5 CRISPR Activation Plasmid (h) - sc-401533-ACT from Santa Cruz Biotechnology
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C5 CRISPR Activation Plasmid (h2) - sc-401533-ACT-2 from Santa Cruz Biotechnology
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C5 Lentiviral Activation Particles (h) - sc-401533-LAC from Santa Cruz Biotechnology
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C5 Lentiviral Activation Particles (h2) - sc-401533-LAC-2 from Santa Cruz Biotechnology
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C5 siRNA (h) - sc-42848 from Santa Cruz Biotechnology
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C5 shRNA Plasmid (h) - sc-42848-SH from Santa Cruz Biotechnology
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C5 shRNA (h) Lentiviral Particles - sc-42848-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4966 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4966 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03911 from Sigma-Aldrich
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C5 siRNA (Human) - CRH0504 from Cohesion Biosciences
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Complement C5 RNAi - H00000727-R01 from Novus Biologicals
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C5 - MBS8238656 from MyBioSource
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Human C5 siRNA - orb261006 from Biorbyt
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C5 shRNA Plasmid (Human) - CHH0504 from Cohesion Biosciences
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C5 miRNA 3'UTR clone - MiUTR1H-01416 from Creative biogene
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