| Gene Symbol |
G6PC3
|
| Entrez Gene |
92579
|
| Alt Symbol |
SCN4, UGRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucose 6 phosphatase, catalytic, 3
|
| Other Description |
G-6-Pase 3|G6Pase 3|G6Pase-beta|glucose-6-phosphatase 3|glucose-6-phosphatase catalytic subunit 3|ubiquitous glucose-6-phosphatase catalytic subunit-related protein|ubiquitously expressed G6Pase catalytic subunit-related protein
|
| Swissprots |
Q8WU15 Q9BUM1
|
| Accessions |
EAW51636 EAW51637 EAW51638 Q9BUM1 BC002494 AAH02494 BC021574 AAH21574 BC062596 BM790097 DB460416 XM_006722179 XP_006722242 XM_011525473 XP_011523775 XM_011525474 XP_011523776 NM_138387 NP_612396 NR_028581 NR_028582
|
| Function |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. {ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:13129915}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:13129915}; Multi-pass membrane protein {ECO:0000269|PubMed:13129915}.
|
| Tissue Specificity |
Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes. {ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:14765991}.
|
| Top Pathways |
Glucagon signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, Carbohydrate digestion and absorption, Glycolysis / Gluconeogenesis
|