Gene Symbol | G6PC3 |
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Entrez Gene | 92579 |
Alt Symbol | SCN4, UGRP |
Species | Human |
Gene Type | protein-coding |
Description | glucose 6 phosphatase, catalytic, 3 |
Other Description | G-6-Pase 3|G6Pase 3|G6Pase-beta|glucose-6-phosphatase 3|glucose-6-phosphatase catalytic subunit 3|ubiquitous glucose-6-phosphatase catalytic subunit-related protein|ubiquitously expressed G6Pase catalytic subunit-related protein |
Swissprots | Q8WU15 Q9BUM1 |
Accessions | EAW51636 EAW51637 EAW51638 Q9BUM1 BC002494 AAH02494 BC021574 AAH21574 BC062596 BM790097 DB460416 XM_006722179 XP_006722242 XM_011525473 XP_011523775 XM_011525474 XP_011523776 NM_138387 NP_612396 NR_028581 NR_028582 |
Function | Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. {ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:13129915}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:13129915}; Multi-pass membrane protein {ECO:0000269|PubMed:13129915}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes. {ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:14765991}. |
Top Pathways | Glucagon signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, Carbohydrate digestion and absorption, Glycolysis / Gluconeogenesis |
Anti-G6PC3 antibody - ab133964 from Abcam
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Anti-SCN4 / G6PC3 Antibody (aa238-286) - LS-C186752 from LifeSpan Bioscience
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Anti-SCN4 / G6PC3 Antibody (aa86-135) IHC-plus⢠- LS-B11558 from LifeSpan Bioscience
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G6PC3 Polyclonal Antibody - bs-13253R from Bioss
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G6PC3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13253R-A350 from Bioss
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G6PC3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13253R-A488 from Bioss
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G6PC3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13253R-A555 from Bioss
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G6PC3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13253R-A647 from Bioss
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G6PC3 Polyclonal Antibody, Cy3 Conjugated - bs-13253R-Cy3 from Bioss
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G6PC3 Polyclonal Antibody, Cy5 Conjugated - bs-13253R-Cy5 from Bioss
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G6PC3 Polyclonal Antibody, Cy5.5 Conjugated - bs-13253R-Cy5.5 from Bioss
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G6PC3 Polyclonal Antibody, Cy7 Conjugated - bs-13253R-Cy7 from Bioss
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G6PC3 Polyclonal Antibody, FITC Conjugated - bs-13253R-FITC from Bioss
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G6PC3 Polyclonal Antibody, Biotin Conjugated - bs-13253R-Biotin from Bioss
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G6PC3 Polyclonal Antibody, HRP Conjugated - bs-13253R-HRP from Bioss
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G6PC3 Antibody - N-terminal region (ARP64608_P050) - ARP64608_P050 from Aviva Systems Biology
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G6PC3 antibody - 23967-1-AP from Proteintech Group
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Anti-G6PC3 (aa 86-135) polyclonal antibody - DPABH-25519 from Creative Diagnostics
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Anti-G6PC3 monoclonal antibody - DCABH-200603 from Creative Diagnostics
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G6PC3 antibody - 23967-1-AP from Acris Antibodies
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G6PC3 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-13253R-A594 from Bioss
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G6PC3 antibody - TA337919 from Acris Antibodies
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G6PC3-Antibody-C-Term - AP22167b from Abgent, a WuXi AppTec company
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G6PC3 Antibody / Glucose-6-phosphatase 3 (F53958) - F53958 from NSJ Bioreagent
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anti-G6PC3 antibody - A003268 from Biobool
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